Surface-enhanced Raman scattering in cancer detection and imaging

被引：324

作者：

Vendrell, Marc ^{[1
]}

Maiti, Kaustabh Kumar ^{[2
]}

Dhaliwal, Kevin ^{[1
]}

Chang, Young-Tae ^{[3
,4
,5
]}

机构：

[1] Univ Edinburgh, Queens Med Res Inst, MRC Ctr Inflammat Res, Edinburgh EH16 4TJ, Midlothian, Scotland

[2] CSIR, NIIST, Thiruvananthapuram 695019, Kerala, India

[3] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[4] Natl Univ Singapore, MedChem Program Life Sci, Singapore 117543, Singapore

[5] ASTAR, Singapore Bioimaging Consortium, Lab Bioimaging Probe Dev, Singapore 138667, Singapore

来源：

TRENDS IN BIOTECHNOLOGY | 2013年 / 31卷 / 04期

基金：

英国医学研究理事会;

关键词：

diagnostics; nanoparticles; nanotechnology; translational research; molecular imaging; oncology; PHOTOTHERMAL THERAPY; GOLD NANOPARTICLES; LIVING MICE; DNA; SPECTROSCOPY; IMMUNOASSAY; CELLS; MARKERS; DIAGNOSIS; RESONANCE;

D O I：

10.1016/j.tibtech.2013.01.013

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Technologies that use surface-enhanced Raman scattering (SERS) have experienced significant growth in biomedical research during the past 4 years. In this review we summarize the progress in SERS for cancer diagnostics, including multiplexed detection and identification of new biomarkers, single-nucleotide polymorphisms, and circulating tumor cells. SERS is also used as a non-invasive tool for cancer imaging with immunoSERS microscopy, histological analysis of biopsies, and in vivo detection of tumors. We discuss the future of SERS probes compatible with multiple imaging modalities and their potential for clinical translation (e.g., endoscope-based and intraoperative imaging as tools for surgical guidance). Moreover, we highlight the potential of SERS agents for targeted drug delivery and photothermal therapy.

引用

页码：249 / 257

页数：9

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