Cyclins, cyclin-dependent kinases and differentiation

被引：106
作者：
Gao, CY [1 ]
Zelenka, PS [1 ]
机构：
[1] NEI,MOL & DEV BIOL LAB,NIH,BETHESDA,MD 20892
来源：
BIOESSAYS | 1997年 / 19卷 / 04期
关键词：
D O I：
10.1002/bies.950190408
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cyclin-dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non-cycling, differentiated cells. This review surveys the available information about cyclins and cyclin-dependent kinases in differentiated cells and explores the possibility that these proteins may have important functions that are independent of cell cycle regulation.
引用
收藏
页码：307 / 315
页数：9
相关论文
共 72 条
[1]   INCREMENT OF THE CYCLIN-D1 MESSENGER-RNA LEVEL IN TPA-TREATED 3 HUMAN MYELOID-LEUKEMIA CELL-LINES - HEL, CMK AND HL-60 CELLS [J].
AKIYAMA, N ;
SASAKI, H ;
KATOH, O ;
SATO, T ;
HIRAI, H ;
YAZAKI, Y ;
SUGIMURA, T ;
TERADA, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 195 (02) :1041-1049
[2]  
Bartkova J, 1996, INT J CANCER, V66, P732, DOI 10.1002/(SICI)1097-0215(19960611)66:6<732::AID-IJC4>3.0.CO
[3]  
2-0
[4]  
BURGER C, 1994, J CELL SCI, V107, P2047
[5]   GROWTH-FACTORS AS SURVIVAL FACTORS - REGULATION OF APOPTOSIS [J].
COLLINS, MKL ;
PERKINS, GR ;
RODRIGUEZTARDUCHY, G ;
NIETO, MA ;
LOPEZRIVAS, A .
BIOESSAYS, 1994, 16 (02) :133-138
[6]   CONSTITUTIVE OVEREXPRESSION OF CDK2 INHIBITS NEURONAL DIFFERENTIATION OF RAT PHEOCHROMOCYTOMA PC12 CELLS [J].
DOBASHI, Y ;
KUDOH, T ;
MATSUMINE, A ;
TOYOSHIMA, K ;
AKIYAMA, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (39) :23031-23037
[7]   CELL-CYCLE CONTROL BY A COMPLEX OF THE CYCLIN HCS26 (PCL1) AND THE KINASE PHO85 [J].
ESPINOZA, FH ;
OGAS, J ;
HERSKOWITZ, I ;
MORGAN, DO .
SCIENCE, 1994, 266 (5189) :1388-1391
[8]   FUNCTIONAL INTERACTIONS OF THE RETINOBLASTOMA PROTEIN WITH MAMMALIAN D-TYPE CYCLINS [J].
EWEN, ME ;
SLUSS, HK ;
SHERR, CJ ;
MATSUSHIME, H ;
KATO, JY ;
LIVINGSTON, DM .
CELL, 1993, 73 (03) :487-497
[9]  
FOTEDAR R, 1995, MOL CELL BIOL, V15, P932
[10]  
Fromm L, 1996, ONCOGENE, V12, P69
12345678