COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy

被引：9

作者：

Khaledi, Mansoor ^{[1
]}

Sameni, Fatemeh ^{[1
]}

Yahyazade, Sheida ^{[2
]}

Radandish, Maedeh ^{[2
]}

Owlia, Parviz ^{[3
]}

Bagheri, Nader ^{[4
]}

Afkhami, Hamed ^{[5
]}

Mahjoor, Mohamad ^{[6
]}

Esmaelpour, Zahra ^{[7
]}

Kohansal, Maryam ^{[8
]}

Aghaei, Farzad ^{[4
]}

机构：

[1] Shahed Univ, Fac Med, Dept Microbiol, Tehran, Iran

[2] Isfahan Univ Med Sci, Sch Med, Dept Immunol, Esfahan, Iran

[3] Shahed Univ, Fac Med, Mol Microbiol Res Ctr, Tehran, Iran

[4] Shahrekord Univ Med Sci, Basic Hlth Sci Inst, Cellular & Mol Res Ctr, Shahrekord, Iran

[5] Shahed Univ, Tehran, Iran

[6] Iran Univ Med Sci, Fac Med, Dept Immunol, Tehran, Iran

[7] Razi Vaccine & Serum Res Inst, Reference Lab Bovine TB, Karaj, Iran

[8] Fasa Univ Med Sci, Dept Med Biotechnol, Fasa, Iran

来源：

FRONTIERS IN MEDICINE | 2022年 / 9卷

关键词：

COVID-19; JAK inhibitors; baricitinib; pacritinib; ruxolitinib; tofacitinib; ACUTE RESPIRATORY SYNDROME; VERSUS-HOST-DISEASE; CYTOKINE STORM; INFLAMMATORY CYTOKINES; SOLUBLE IL-6R; CUTTING EDGE; T-CELLS; INTERLEUKIN-6; BARICITINIB; RECEPTOR;

D O I：

10.3389/fmed.2022.961027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence proposed that the severity of the coronavirus disease 2019 (COVID-19) in patients is a consequence of cytokine storm, characterized by increased IL-1 beta, IL-6, IL-18, TNF-alpha, and IFN-gamma. Hence, managing the cytokine storm by drugs has been suggested for the treatment of patients with severe COVID-19. Several of the proinflammatory cytokines involved in the pathogenesis of COVID-19 infection recruit a distinct intracellular signaling pathway mediated by JAKs. Consequently, JAK inhibitors, including baricitinib, pacritinib, ruxolitinib, and tofacitinib, may represent an effective therapeutic strategy for controlling the JAK to treat COVID-19. This study indicates the mechanism of cytokine storm and JAK/STAT pathway in COVID-19 as well as the medications used for JAK/STAT inhibitors.

引用

页数：20

共 192 条

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