Electrochemical investigation on the interaction of diclofenac with DNA and its application to the construction of a graphene-based biosensor

被引：23
作者：
Wei, Lili [1 ]
Borowiec, Joanna [1 ]
Zhu, Lihua [1 ]
Zhang, Jingdong [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China
[2] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
来源：
JOURNAL OF SOLID STATE ELECTROCHEMISTRY | 2012年 / 16卷 / 12期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
Diclofenac; DNA; Interaction; Graphene oxide; Photodegradation; GRAPHITE ELECTRODE; BETA-CYCLODEXTRIN; ORYZIAS-LATIPES; NEUTRAL RED; OXIDATION; COMPLEX; SODIUM; DRUG; CARBAMAZEPINE; HYBRIDIZATION;
D O I：
10.1007/s10008-012-1815-3
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
We have investigated the interaction between diclofenac and deoxyribonucleic acid (DNA) by the electrochemical method. On glassy carbon electrode, the voltammetric curve of diclofenac showed an oxidation peak, which was obviously influenced by the addition of DNA. Accordingly, a series of electrochemical experiments were carried out to elucidate the interaction between diclofenac and DNA. Based on the diclofenac-DNA interaction, a biosensor for diclofenac was developed. When a film of DNA was immobilized on the electrode surface, DNA showed an oxidation signal promoted by graphene oxide. Due to the diclofenac-DNA interaction, the peak current of DNA decreased and the peak potential shifted positively with increasing the concentration of diclofenac. The response of the biosensor was linear to the concentration of diclofenac in the range of 1 to 130 mu M. Using such a biosensor, the photodegradation of diclofenac was successfully monitored.
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收藏
页码：3817 / 3823
页数：7
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