Background: Bleomycin (BLM), a chemotherapeutic agent is indicated in the management of some types of cancers. This drug produces a dose-dependent pulmonary fibrosis (PF) in most patients as well as experimental animals through oxidative injury. This study aimed to investigate the effect of gallic acid (GA), a polyphenolic compound, against PF-induce by BLM in rats. Materials and methods: The rats were given GA orally at doses (50, 100, and 200 mg/kg/day) for 7 consecutive days before the administration of single intratracheal (it) instillation of BLM at 7.5 IU/kg. GA doses were continued for 21 days after BLM exposure. The regulatory effects of GA on BLM-induced pulmonary toxicity were determined by assaying oxidative stress biomarkers, lung and serum cytokine levels, and by histopathological examination of lung tissue. Results: The results showed that intratracheal BLM administration significantly increased the inflammatory or fibrotic changes, collagen content, levels of malondialdehyde (MDA), and pro-inflammatory cytokines such as TNF-alpha and IL1 beta in lung. Also, it significantly decreased non-enzymatic (total thiol) and enzymatic (glutathione peroxidase (GPx)) antioxidant contents in the rats' lung tissue. However, oral administration of GA reversed all of these biochemical indices as well as histopathological alterations induced by BLM. Conclusion: Results of the present study demonstrate that GA, by its antioxidant properties, attenuates oxidative damage and fibrosis induced by BLM. Thus, an effective supplement with GA as an adjuvant therapy may be a very promising compound in reducing the side effects of BLM. (C) 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.
机构:
Univ Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USAUniv Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USA
Abid, SH
;
Malhotra, V
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Univ Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USAUniv Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USA
Malhotra, V
;
Perry, MC
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Univ Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USAUniv Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USA
机构:
Chung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Taichung Vet Gen Hosp, Div Thorac Surg, Taichung 407, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Chuang, Cheng-Yen
;
Liu, Hsiang-Chun
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Taichung Vet Gen Hosp, Dept Educ & Res, Taichung 407, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Liu, Hsiang-Chun
;
Wu, Li-Chen
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Natl Chi Nan Univ, Dept Appl Chem, Puli 545, Nantou, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Wu, Li-Chen
;
Chen, Chiu-Yuan
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Nanhua Univ, Grad Inst Nat Healing Sci, Chiayi, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Chen, Chiu-Yuan
;
Chang, Jinghua Tsai
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Chung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Chang, Jinghua Tsai
;
Hsu, Shih-Lan
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Chung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Taichung Vet Gen Hosp, Dept Educ & Res, Taichung 407, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
机构:
Univ Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USAUniv Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USA
Abid, SH
;
Malhotra, V
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机构:
Univ Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USAUniv Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USA
Malhotra, V
;
Perry, MC
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Univ Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USAUniv Missouri, Ellis Fischel Canc Ctr, Div Hematol Med Oncol, W Columbia, MO 65203 USA
机构:
Chung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Taichung Vet Gen Hosp, Div Thorac Surg, Taichung 407, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Chuang, Cheng-Yen
;
Liu, Hsiang-Chun
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h-index: 0
机构:
Taichung Vet Gen Hosp, Dept Educ & Res, Taichung 407, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Liu, Hsiang-Chun
;
Wu, Li-Chen
论文数: 0引用数: 0
h-index: 0
机构:
Natl Chi Nan Univ, Dept Appl Chem, Puli 545, Nantou, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Wu, Li-Chen
;
Chen, Chiu-Yuan
论文数: 0引用数: 0
h-index: 0
机构:
Nanhua Univ, Grad Inst Nat Healing Sci, Chiayi, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Chen, Chiu-Yuan
;
Chang, Jinghua Tsai
论文数: 0引用数: 0
h-index: 0
机构:
Chung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Chang, Jinghua Tsai
;
Hsu, Shih-Lan
论文数: 0引用数: 0
h-index: 0
机构:
Chung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan
Taichung Vet Gen Hosp, Dept Educ & Res, Taichung 407, TaiwanChung Shan Med Univ, Inst Med & Mol Toxicol, Taichung 40203, Taiwan