Biodegradable Mesostructured Polymer Membranes

被引：6

作者：

Tian, Bozhi ^{[1
,2
]}

Shankarappa, Sahadev A. ^{[1
,2
]}

Chang, Homer H. ^{[1
,2
]}

Tong, Rong ^{[1
,2
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Anesthesiol, Div Crit Care Med,Childrens Hosp Boston, Boston, MA 02115 USA

[2] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

NANO LETTERS | 2013年 / 13卷 / 09期

关键词：

Biodegradable; mesostructured; membranes; tissue engineering; ORDERED MESOPOROUS POLYMERS; NANOPOROUS POLYMERS; CARBON FRAMEWORKS; SCAFFOLDS; DEGRADATION; STRATEGIES; STABILITY; DESIGN;

D O I：

10.1021/nl402251x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The extracellular matrix (ECM) has a quasi-ordered reticular mesostructure with feature sizes on the order of tenths of to a few hundred nanometers. Approaches to preparing biodegradable synthetic scaffolds for engineered tissues that have the critical mesostructure to mimic ECM are few. Here we present a simple and general solvent evaporation-induced self-assembly (EISA) approach to preparing concentrically reticular mesostructured polyol-polyester membranes. The mesostructures were formed by a novel self-assembly process without covalent or electrostatic interactions, which yielded feature sizes matching those of ECM. The mesostructured materials were nonionic, hydrophilic, and water-permeable and could be shaped into arbitrary geometries such as conformally molded tubular sacs and micropatterned meshes. Importantly, the mesostructured polymers were biodegradable and were used as ultrathin temporary substrates for engineering vascular tissue constructs.

引用

页码：4410 / 4415

页数：6

共 42 条

[31] Electrospun PLGA nanofiber scaffolds for articular cartilage reconstruction:: mechanical stability, degradation and cellular responses under mechanical stimulation in vitro [J].