Self-Referenced Silicon Nitride Array Microring Biosensor for Toxin Detection Using Glycans at Visible Wavelength

被引：7

作者：

Ghasemi, Farshid ^{[1
]}

Eftekahr, Ali A. ^{[1
]}

Gottfried, David S. ^{[2
]}

Song, Xuezheng ^{[3
]}

Cummings, Richard D. ^{[3
]}

Adibi, Ali ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Elect & Comp Engn, 777 Atlantic Dr, Atlanta, GA 30332 USA

[2] Georgia Inst Technol, Inst Elect & Nanotechnol, Atlanta, GA 30332 USA

[3] Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30332 USA

来源：

NANOSCALE IMAGING, SENSING, AND ACTUATION FOR BIOMEDICAL APPLICATIONS X | 2013年 / 8594卷

基金：

美国国家科学基金会;

关键词：

Sensing; Microring resonator; Silicon nitride; Glycan; Cholera Toxin Subunit B; Ricinus Communis Agglutinin I; LABEL-FREE DETECTION; CHOLERA-TOXIN; RESONATORS; SENSOR; CHIP;

D O I：

10.1117/12.2005653

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We report on application of on-chip referencing to improve the limit-of-detection (LOD) in compact silicon nitride (SiN) microring arrays. Microring resonators, fabricated by e-beam lithography and fluorine-based etching, are designed for visible wavelengths (656nm) and have a footprint of 20 x 20 mu m. GM1 ganglioside is used as the specific ligand for recognition of Cholera Toxin Subunit B (CTB), with Ricinus Communis Agglutinin I (RCA I) as a negative control. Using micro-cantilever based printing less than 10 pL of glycan solution is consumed per microring. Real-time data on analyte binding is extracted from the shifts in resonance wavelengths of the microrings.

引用

页数：9

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