Local bacteria affect the efficacy of chemotherapeutic drugs

被引：239
作者：
Lehouritis, Panos [1 ]
Cummins, Joanne [1 ]
Stanton, Michael [1 ]
Murphy, Carola T. [1 ]
McCarthy, Florence O. [2 ]
Reid, Gregor [3 ,4 ]
Urbaniak, Camilla [3 ,4 ]
Byrne, William L. [1 ]
Tangney, Mark [1 ]
机构：
[1] Univ Coll Cork, Cork Canc Res Ctr, Cork, Ireland
[2] Univ Coll Cork, Dept Chem & Analyt & Biol Chem Res Facil, Cork, Ireland
[3] Lawson Hlth Res Inst, London, ON N6A 4V2, Canada
[4] Univ Western Ontario, Dept Microbiol & Immunol, London, ON, Canada
来源：
SCIENTIFIC REPORTS | 2015年 / 5卷
关键词：
INVASIVE BLADDER-CANCER; ESCHERICHIA-COLI; COLORECTAL-CANCER; CALMETTE-GUERIN; PROSTATE-CANCER; MICROBIOTA; THERAPY; BIOTRANSFORMATION; INFECTIONS; DELIVERY;
D O I：
10.1038/srep14554
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this study, the potential effects of bacteria on the efficacy of frequently used chemotherapies was examined. Bacteria and cancer cell lines were examined in vitro and in vivo for changes in the efficacy of cancer cell killing mediated by chemotherapeutic agents. Of 30 drugs examined in vitro, the efficacy of 10 was found to be significantly inhibited by certain bacteria, while the same bacteria improved the efficacy of six others. HPLC and mass spectrometry analyses of sample drugs (gemcitabine, fludarabine, cladribine, CB1954) demonstrated modification of drug chemical structure. The chemoresistance or increased cytotoxicity observed in vitro with sample drugs (gemcitabine and CB1954) was replicated in in vivo murine subcutaneous tumour models. These findings suggest that bacterial presence in the body due to systemic or local infection may influence tumour responses or off-target toxicity during chemotherapy.
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页数：12
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