Alcohol, tobacco and coffee consumption and liver disease severity among individuals with Chronic Hepatitis B infection in North America

被引：6

作者：

Brahmania, Mayur ^{[1
]}

Liu, Stephen ^{[2
]}

Wahed, Abdus S. ^{[3
]}

Yim, Colina ^{[1
]}

Hansen, Bettina E. ^{[1
,4
]}

Khalili, Mandana ^{[5
]}

Terrault, Norah A. ^{[5
]}

Lok, Anna S. ^{[6
]}

Ghany, Marc ^{[7
]}

Wang, Junyao ^{[2
]}

Wong, David ^{[1
]}

Janssen, Harry L. A. ^{[1
]}

Lau, Daryl T-Y ^{[8
]}

Chung, Raymond T. ^{[9
]}

Roberts, Lewis R. ^{[10
]}

Hassan, Mohamed A. ^{[11
]}

Di Bisceglie, Adrian M. ^{[12
]}

Lisker-Melman, Mauricio ^{[13
]}

Juan, Joshua ^{[14
]}

Feld, Jordan ^{[14
]}

Patel, Keyur ^{[14
]}

Lee, William M. ^{[15
]}

Murakami, Carol S. ^{[15
]}

Perrillo, Robert ^{[16
]}

Do, Son ^{[17
]}

Han, Steven-Huy B. ^{[18
]}

Tran, Tram T. ^{[19
]}

Cooper, Stewart L. ^{[20
]}

Fontana, Robert J. ^{[21
]}

Tsai, Naoky ^{[22
]}

Younoszai, Barak ^{[22
]}

Fried, Michael W. ^{[23
]}

Muir, Andrew ^{[24
]}

Evon, Donna ^{[23
]}

Darling, Jama M. ^{[23
]}

Carithers, Robert C. ^{[25
]}

Shuhart, Margaret ^{[26
]}

Kowdley, Kris, V ^{[27
]}

Wang, Chia C. ^{[27
]}

Sterling, Richard K. ^{[28
]}

Luketic, Velimir A. ^{[28
]}

Liang, T. Jake ^{[29
]}

Hoofnagle, Jay H. ^{[29
]}

Doo, Edward ^{[29
]}

Chang, Kyong-Mi ^{[30
]}

Park, Jang-June ^{[30
]}

Belle, Steven H. ^{[31
]}

Cloonan, Yona ^{[31
]}

Kleiner, David ^{[32
]}

机构：

[1] Univ Hlth Network, Toronto Gen Hosp, Div Gastroenterol, Toronto, ON, Canada

[2] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA

[3] Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA

[4] Univ Toronto, IHPME, Toronto, ON, Canada

[5] Univ Calif San Francisco, Div Gastroenterol & Hepatol, San Francisco, CA 94143 USA

[6] Univ Michigan, Div Gastroenterol & Hepatol, Ann Arbor, MI 48109 USA

[7] NIDDK, Liver Dis Branch, NIH, Bethesda, MD 20892 USA

[8] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[9] Massachusetts Gen Hosp, Boston, MA 02114 USA

[10] Mayo Clin, Rochester, MN USA

[11] Univ Minnesota, Minneapolis, MN USA

[12] St Louis Univ, Sch Med, St Louis, MO USA

[13] Washington Univ, Sch Med, St Louis, MO USA

[14] Toronto Gen Hosp, Toronto, ON, Canada

[15] Univ Texas Southwestern Med Ctr Dallas, Div Digest & Liver Dis, Dallas, TX 75390 USA

[16] Baylor Univ, Med Ctr, Dallas, TX USA

[17] Univ Texas Southwestern, Dallas, TX USA

[18] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[19] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[20] Calif Pacific Med Ctr, Div Gen & Transplant Hepatol, San Francisco, CA USA

[21] Univ Michigan, Ann Arbor, MI 48109 USA

[22] Univ Hawaii, Queens Med Ctr, Honolulu, HI 96822 USA

[23] Univ N Carolina, Chapel Hill, NC 27515 USA

[24] Duke Univ, Med Ctr, Durham, NC USA

[25] Univ Washington, Med Ctr, Seattle, WA 98195 USA

[26] Harborview Med Ctr, Seattle, WA USA

[27] Virginia Mason Med Ctr, Seattle, WA 98101 USA

[28] Virginia Commonwealth Univ Hlth Syst, Richmond, VA USA

[29] NIH, Bldg 10, Bethesda, MD 20892 USA

[30] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[31] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA

[32] NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

ANNALS OF HEPATOLOGY | 2020年 / 19卷 / 04期

关键词：

Chronic Hepatitis B; Alcohol; Tobacco; Coffee; Hepatitis B Research Network; HEPATOCELLULAR-CARCINOMA; CIGARETTE-SMOKING; VIRUS-INFECTIONS; RISK; CANCER; MORTALITY; DRINKING; CAFFEINE; FIBROSIS; LESIONS;

D O I：

10.1016/j.aohep.2020.01.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Introduction and objectives: The prevalence of alcohol, tobacco, and coffee use and association with liver health among North Americans with Chronic Hepatitis B (CHB) infection has not been well described. Materials and methods: The Hepatitis B Research Network includes an observational study of untreated CHB adults enrolled at 21 sites in the United States and Canada. Alcohol use was categorized as none, moderate, and at-risk based on the definition from the National Institute on Alcohol Abuse and Alcoholism; tobacco use as never, current and former; coffee use as none, 1-2 cups/day, and >= 3 cups/day. Linear regression and linear mixed models were used to associate lifestyle behaviors with ALT and FIB-4 values. Results: 1330 participants met eligibility: 53% males, 71% Asian and the median age was 42 years (IQR: 34-52). Median ALT was 33 U/L (IQR: 22-50), 37% had HBV DNA <10(3) IU/mL, 71% were HBeAg negative, and 65% had a FIB-4 <1.45. At baseline, 8% of participants were at-risk alcohol drinkers, 11% were current smokers and 92% drank <3 cups of coffee/day. Current tobacco and 'at-risk' alcohol use, were significantly associated with elevated ALT levels in univariable analyses, however, these associations were not statistically significant when controlling for sociodemographic and HBV characteristics. Conclusions: In this large diverse cohort of untreated CHB participants, at-risk alcohol use, current tobacco use and limited coffee consumption did not have an association with high ALT and FIB-4 values. In contrast, significant associations were found between the frequency of these lifestyle behaviors and sociodemographic factors. (C) 2020 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U.

引用

页码：437 / 445

页数：9

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