Design, Synthesis, and In vitro Antitumor Evaluation of Novel Phenylaminopyrimidine Derivatives

被引：1

作者：

Zheng, Youguang ^{[1
,2
]}

Zheng, Ming ^{[2
]}

Liu, Yi ^{[1
]}

Xue, Yunsheng ^{[1
]}

Zhang, Ling ^{[1
]}

An, Lin ^{[1
]}

Liu, Ling ^{[1
]}

Ji, Min ^{[2
]}

机构：

[1] Xuzhou Med Coll, Coll Pharm, Xuzhou 221004, Peoples R China

[2] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China

来源：

MEDICINAL CHEMISTRY | 2013年 / 9卷 / 03期

关键词：

Phenylaminopyrimidine derivatives; U937; K562; antitumor activity; AURORA KINASE INHIBITORS; POTENT; DISCOVERY; VX-680; CANCER;

D O I：

10.2174/1573406411309030004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two series of novel phenylaminopyrimidine derivatives were designed and synthesized. All target compounds were determined against the human acute monocytic leukemia cell line U937 and the human chronic myeloid leukemia cell line K562 in vitro. Some of the target compounds demonstrated significant inhibitory activity against both cell lines. Compared with the control drug VX-680, 8a, 8e, 8g, 8h, 8j, and 8k demonstrated more potent antitumor activity. The structures of all target compounds were identified by H-1-NMR, C-13-NMR, IR, MS, and EA.

引用

页码：340 / 350

页数：11

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