Poxvirus preparation CONPIND initiates production of the major inflammatory mediators IL-1 alpha and TNF-alpha in human whole blood and in blood mononuclear cell cultures

被引：6

作者：

Ahne, W

Mayr, A

机构：

[1] Veterinary Faculty, University of Munich, D-80539, Munich

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 1997年 / 20卷 / 02期

关键词：

poxvirus; paramunity inducer; CONPIND; interleukin; 1; alpha; tumour necrosis factor alpha; human whole blood; human blood mononuclear cell culture;

D O I：

10.1016/S0147-9571(96)00040-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The poxvirus preparation CONPIND initiated the production of the two major inflammatory mediators interleukin-1 alpha (IL-1 alpha) and tumour necrosis factor-alpha (TNF-alpha) in whole blood and in blood mononuclear cell cultures of man at 37 degrees C within 12-48 h. The release of the cytokines followed a dose-efficacy curve. High levels of IL1-alpha (up to 810 pg/ml) and TNF-alpha (up to 533 pg/ml) were determined by sandwich enzyme-linked immunosorbent assay.

引用

页码：139 / 145

页数：7

共 10 条

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