Poly(ethylene glycol)-crosslinked fullerenes for high efficient phototherapy

被引：19

作者：

Lee, Dong Jin ^{[1
]}

Ahn, Yong Sik ^{[1
]}

Youn, Yu Seok ^{[2
]}

Lee, Eun Seong ^{[1
]}

机构：

[1] Catholic Univ Korea, Div Biotechnol, Puchon 420743, Gyeonggi Do, South Korea

[2] Sungkyunkwan Univ, Coll Pharm, Suwon, South Korea

来源：

POLYMERS FOR ADVANCED TECHNOLOGIES | 2013年 / 24卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

multimeric fullerene; photothermal; photodynamic; cancer therapy; rheumatoid arthritis therapy; 3-DIETHYLAMINOPROPYL-BEARING GLYCOL CHITOSAN; MULTIFUNCTIONAL POLYMERIC MICELLE; GENE DELIVERY; DRUG; THERAPY; NANOGEL; CARRIER;

D O I：

10.1002/pat.3074

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(ethylene glycol)-crosslinked multimeric C60 was developed for use in photothermal/photodynamic therapy of malignant cells. We showed that: (i) the tumor surface temperature on KB tumor-bearing nude mice treated with multimeric C60 reached about 44?degrees C; (ii) this hyperthermic condition and tremendous singlet oxygen generation from multimeric C60 resulted in significant tumor volume regression in KB tumor-bearing nude mice; and (iii) multimeric C60 also efficiently inhibited arthritic progress in the arthritis-induced DBA/1?J mice model. This multimeric C60 may be useful for photothermal/photodynamic cell ablation in various malignant cells. Copyright (c) 2012 John Wiley & Sons, Ltd.

引用

页码：220 / 227

页数：8

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