Expression of human GFRα-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves

被引：18

作者：

Hase, A

Suzuki, H

Arahata, K

Akazawa, C ^{[1
]}

机构：

[1] NCNP, Natl Inst Neurosci, Dept Neuromuscular Res, Tokyo 1878502, Japan

[2] Nippon Med Sch, Dept Pharmacol, Tokyo 1138602, Japan

[3] Japan Sci & Technol, CREST, Tokyo, Japan

来源：

NEUROSCIENCE LETTERS | 1999年 / 269卷 / 01期

关键词：

glial cell line-derived neurotrophic factor; glial cell line-derived neurotrophic factor receptor alpha; GFR alpha-1; human; immunohistochemistry; neuromuscular junction; reverse transcriptase polymerase chain reaction; skeletal muscle;

D O I：

10.1016/S0304-3940(99)00419-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Motor neurons have been known to require a wide variety of neurotrophic factors for their survival. As one of the target-derived trophic factors, glial cell line-derived neurotrophic factor (GDNF) has been shown to exert its effects on motor neurons via a receptor complex including GDNF receptor alpha 1 (GFR alpha-1). Immunoreactivity of GFR alpha-1 was observed at myelinated peripheral nerves and neuromuscular junction (NMJ) of human skeletal muscles. Reverse transcriptase polymerase chain reaction (RT-PCR) analyses showed that mRNA of GFR alpha-1 existed in the ventral horn of hu man spinal cord, but not in the skeletal muscles. The results suggested that GFRa-1 mig ht play a key role for uptake and internalization of GDNF at the human NMJ. (C) 1999 Elsevier Science ireland Ltd. All rights reserved.

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页码：55 / 57

页数：3

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