Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors

被引：18

作者：

Alvarez, Florencia ^{[1
]}

Grillo, Claudia A. ^{[1
]}

Schilardi, Patricia L. ^{[1
]}

Rubert, Aldo ^{[1
]}

Benitez, Guillermo ^{[1
]}

Lorente, Carolina ^{[1
]}

Fernandez Lorenzo de Mele, Monica ^{[1
,2
]}

机构：

[1] Natl Univ La Plata, Fac Ciencias Exactas, Dept Quim, Inst Invest Fisicoquim Teor & Aplicadas INIFTA,CC, RA-1900 La Plata, Argentina

[2] Natl Univ La Plata, Fac Ingn, RA-1900 La Plata, Argentina

来源：

ACS APPLIED MATERIALS & INTERFACES | 2013年 / 5卷 / 02期

关键词：

intrauterine device; copper; copper ions; pterin; 6-mercaptopurine; cytotoxicity; SIMULATED UTERINE FLUID; VOLTAMMETRIC DETERMINATION; SILVER ELECTRODE; METALLIC COPPER; IN-VITRO; IONS; AU(111); BEHAVIOR; SAMS; ABSORPTION;

D O I：

10.1021/am3025307

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The copper intrauterine device (IUD) based its contraceptive action on the release of cupric ions from a copper wire. Immediately after the insertion, a burst release of copper ions occurs, which may be associated to a variety of side effects. 6-Mercaptopurine (6-MP) and pterin (PT) have been proposed as corrosion inhibitors to reduce this harmful release. Pretreatments with 1 X 10(-4) M 6-MP and 1 X 10(-4) M PT solutions with 1h and 3h immersion times were tested. Conventional electrochemical techniques, EDX and XPS analysis, and cytotoxicity assays with HeLa cell line were employed to investigate the corrosion behavior and biocompatibility of copper with and without treatments. Results showed that copper samples treated with PT and 6-MP solutions for 3 and 1 h, respectively, are more biocompatible than those without treatment. Besides, the treatment reduces the burst release effect of copper in simulated uterine solutions during the first week after the insertion. It was concluded that PT and 6-MP treatments are promising strategies able to reduce the side effects related to the "burst release" of copper-based IUD without altering the contraceptive action.

引用

页码：249 / 255

页数：7

共 44 条

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