Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes

被引：66

作者：

Lin, Zhen ^{[1
]}

Liu, Yi ^{[2
,3
]}

Ma, Xueming ^{[1
]}

Hu, Shaoyu ^{[1
]}

Zhang, Jiawei ^{[1
]}

Wu, Qian ^{[1
]}

Ye, Wenbin ^{[1
]}

Zhu, Siyuan ^{[1
]}

Yang, Dehong ^{[1
]}

Qu, Dongbin ^{[1
]}

Jiang, Jianming ^{[1
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Spinal Surg, Guangzhou 510515, Guangdong, Peoples R China

[2] Vrije Univ Amsterdam, Acad Ctr Dent Amsterdam ACTA, Dept Oral Implantol & Prosthet Dent, MOVE Res Inst, Amsterdam, Netherlands

[3] Univ Amsterdam, Amsterdam, Netherlands

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

国家教育部博士点专项基金资助; 中国国家自然科学基金;

关键词：

GUIDED FOCUSED ULTRASOUND; RADIOFREQUENCY ABLATION; THERMAL ABLATION; MECHANISMS; THERAPY; TUMORS; NERVE; CELLS;

D O I：

10.1038/srep11709

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study investigates therapeutic efficacy of photothermal therapy (PTT) in an orthotropic xenograft model of bone metastasis of breast cancer. The near-infrared (NIR) irradiation on Multi-Walled Carbon Nanotubes (MWNTs) resulted in a rapid heat generation which increased with the MWNTs concentration up to 100 mu g/ml. MWNTs alone exhibited no toxicity, but inclusion of MWNTs dramatically decreased cell viability when combined with laser irradiation. Thermographic observation revealed that treatment with 10 mu g MWNTs followed by NIR laser irradiation resulted in a rapid increase in temperature up to 73.4 +/- 11.98 degrees C in an intraosseous model of bone metastasis of breast cancer. In addition, MWNTs plus NIR laser irradiation caused a remarkably greater suppression of tumor growth compared with treatment with either MWNTs injection or NIR irradiation alone, significantly reducing the amount of tumor-induced bone destruction. All these demonstrate the efficacy of PTT with MWNTs for bone metastasis of breast cancer.

引用

页数：10

共 31 条

[1] Concurrent administration of zoledronic acid and irradiation leads to improved bone density, biomechanical strength, and microarchitecture in a mouse model of tumor-induced osteolysis [J].

Arrington, Sarah A. ;

Damron, Timothy A. ;

Mann, Kenneth A. ;

Allen, Matthew J. .

JOURNAL OF SURGICAL ONCOLOGY, 2008, 97 (03) :284-290

[2] Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation [J].

Burke, Andrew ;

Ding, Xuanfeng ;

Singh, Ravi ;

Kraft, Robert A. ;

Levi-Polyachenko, Nicole ;

Rylander, Marissa Nichole ;

Szot, Chris ;

Buchanan, Cara ;

Whitney, Jon ;

Fisher, Jessica ;

Hatcher, Heather C. ;

D'Agostino, Ralph, Jr. ;

Kock, Nancy D. ;

Ajayan, P. M. ;

Carroll, David L. ;

Akman, Steven ;

Torti, Frank M. ;

Torti, Suzy V. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (31) :12897-12902

[3] Emerging anti-cancer molecular mechanisms of aminobisphosphonates [J].

Caraglia, M ;

Santini, D ;

Marra, M ;

Vincenzi, B ;

Tonini, G ;

Budillon, A .

[4] Breast cancer bone metastasis and current small therapeutics [J].

Cicek, Muzaffer ;

Oursler, Merry Jo .

CANCER AND METASTASIS REVIEWS, 2006, 25 (04) :635-644

[5]

Elsie KM, 2010, PAN AFR MED J, V5

[6] Photothermal Response of Human and Murine Cancer Cells to Multiwalled Carbon Nanotubes after Laser Irradiation [J].

Fisher, Jessica W. ;

Sarkar, Saugata ;

Buchanan, Cara F. ;

Szot, Christopher S. ;

Whitney, Jon ;

Hatcher, Heather C. ;

Torti, Suzy V. ;

Rylander, Christopher G. ;

Rylander, Marissa Nichole .

CANCER RESEARCH, 2010, 70 (23) :9855-9864

[7]

Gonzalez-Angulo AM, 2007, ADV EXP MED BIOL, V608, P1

[8] A histological evaluation and in vivo assessment of intratumoral near infrared photothermal nanotherapy-induced tumor regression [J].

Green, Hadiyah N. ;

Crockett, Stephanie D. ;

Martyshkin, Dmitry V. ;

Singh, Karan P. ;

Grizzle, William E. ;

Rosenthal, Eben L. ;

Mirov, Sergey B. .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 9 :5093-5102

[9] Fundamental transmitting properties of carbon nanotube antennas [J].

Hanson, GW .

IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION, 2005, 53 (11) :3426-3435

[10] Photothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite [J].

Hashida, Yasuhiko ;

Tanaka, Hironori ;

Zhou, Shuwen ;

Kawakami, Shigeru ;

Yamashita, Fumiyoshi ;

Murakami, Tatsuya ;

Umeyama, Tomokazu ;

Imahori, Hiroshi ;

Hashida, Mitsuru .

JOURNAL OF CONTROLLED RELEASE, 2014, 173 :59-66

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