THE BIOLOGY AND THEORIES OF AGING

被引：1

作者：

Stanic, Snezana M. ^{[1
]}

Matic, Sanja Lj ^{[1
,2
]}

机构：

[1] Univ Kragujevac, Fac Sci, Dept Biol & Ecol, Radoja Domancivica 12, Kragujevac 34000, Serbia

[2] Univ Kragujevac, Inst Informat Technol, Dept Sci, Jovana Cvijica Bb, Kragujevac 34000, Serbia

来源：

THEORETICAL BIOLOGY FORUM | 2019年 / 112卷 / 1-2期

关键词：

Theories; aging; genetic conditionality; environmental factor; epigenetic factor; LIFE-SPAN; GENES; MUTATIONS; GENETICS; DAMAGE;

D O I：

10.19272/201911402006

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Aging is a natural, time-dependent process characterized by irreversible changes in the molecules, cells, tissues, and organs. It occurs as a result of cumulative damage at different levels of the organization, in particular by damaging proteins and DNA. There is no single definition, nor a unique attitude aboutwhen and how age arises and what are its causes. The process is extremely complex and most likely a consequence of the effects of different mechanisms (not only genetic but also acquired) that lead to disrupt homeostasis, reduce stress resistance and the more frequent occurrence of the disease. There aremany classifications of theories about aging and they often contradict one another. No one theory is sufficiently able to explain the process of aging. The aim of this work is to analyze the different aspects, main characteristics of the aging, individual differences in the speed of this process and theories about the mechanisms of aging.

引用

页码：79 / 89

页数：11

共 33 条

[1]

ABRASS IB, 1990, WESTERN J MED, V153, P641

[2] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].

AMES, BN ;

SHIGENAGA, MK ;

HAGEN, TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922

[3] Nuclear DNA Damage as a Direct Cause of Aging [J].

Best, Benjamin P. .

REJUVENATION RESEARCH, 2009, 12 (03) :199-208

[4] Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [J].

Blasco, MA ;

Lee, HW ;

Hande, MP ;

Samper, E ;

Lansdorp, PM ;

DePinho, RA ;

Greider, CW .

CELL, 1997, 91 (01) :25-34

[5] Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery [J].

de Magalhaes, Joao Pedro ;

Wuttke, Daniel ;

Wood, Shona H. ;

Plank, Michael ;

Vora, Chintan .

PHARMACOLOGICAL REVIEWS, 2012, 64 (01) :88-101

[6]

Dobzhansky T., 1962, MANKIND EVOLVING EVO

[7] Genes, Environments, Personality, and Successful Aging: Toward a Comprehensive Developmental Model in Later Life [J].

Eaton, Nicholas R. ;

Krueger, Robert F. ;

South, Susan C. ;

Gruenewald, Tara L. ;

Seeman, Teresa E. ;

Roberts, Brent W. .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2012, 67 (05) :480-488

[8] Genetics of aging [J].

Finch, CE ;

Tanzi, RE .

SCIENCE, 1997, 278 (5337) :407-411

[9] The Werner syndrome protein is a DNA helicase [J].

Gray, MD ;

Shen, JC ;

KamathLoeb, AS ;

Blank, A ;

Sopher, BL ;

Martin, GM ;

Oshima, J ;

Loeb, LA .

NATURE GENETICS, 1997, 17 (01) :100-103

[10] Does oxidative damage to DNA increase with age? [J].

Hamilton, ML ;

Van Remmen, H ;

Drake, JA ;

Yang, H ;

Guo, ZM ;

Kewitt, K ;

Walter, CA ;

Richardson, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10469-10474

← 1 2 3 4 →