The use of high-sensitivity assays for C-reactive protein in clinical practice

被引：110

作者：

Musunuru, Kiran ^{[1
]}

Kral, Brian G.

Blumenthal, Roger S. ^{[1
]}

Fuster, Valentin ^{[2
,3
]}

Campbell, Catherine Y.

Gluckman, Ty J.

Lange, Richard A. ^{[1
]}

Topol, Eric J. ^{[4
]}

Willerson, James T. ^{[5
]}

Desai, Milind Y. ^{[6
,7
]}

Davidson, Michael H. ^{[8
]}

Mora, Samia ^{[9
,10
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Johns Hopkins Ciccarone Prevent Cardiol Ctr, Baltimore, MD 21287 USA

[2] Mt Sinai Sch Med, Zena & Michacl A Wiener Cardiovasc Inst, New York, NY USA

[3] Mt Sinai Sch Med, Marie Jose & Henry R Kravis Ctr Cardiovasc Hlth, New York, NY USA

[4] Scripps Translat Sci Inst, La Jolla, CA USA

[5] St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX USA

[6] Cleveland Clin Fdn, Dept Cardiovasc Med, Cleveland, OH 44195 USA

[7] Case Western Reserve Univ, Lerner Coll Med, Cleveland, OH 44106 USA

[8] Univ Chicago, Sch Med, Chicago, IL 60637 USA

[9] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent, Boston, MA 02115 USA

[10] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc Med, Boston, MA 02115 USA

来源：

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE | 2008年 / 5卷 / 10期

关键词：

coronary disease; diabetes mellitus; prevention; risk factors; stroke;

D O I：

10.1038/ncpcardio1322

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High-sensitivity assays that accurately measure levels of the inflammatory biomarker C-reactive protein have been proposed for use in assessments of risk for cardiovascular disease (CVD). A growing body of evidence supports recommendations for these tests in selected asymptornatic individuals deemed to be at intermediate risk of CVD according to traditional risk-factor assessments and who do not already warrant chronic treatment with aspirin and statin therapy. Data suggests that these high-sensitivity assays should be used in combination with measurements of LDL-cholesterol levels to assist risk stratification of selected patients for prevention of CVD.

引用

页码：621 / 635

页数：15

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