Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids

被引：68

作者：

Jin, Shubin ^{[1
,2
]}

Ma, Xiaowei ^{[1
,2
]}

Ma, Huili ^{[1
,2
]}

Zheng, Kaiyuan ^{[1
,2
]}

Liu, Juan ^{[1
,2
]}

Hou, Shuai ^{[3
]}

Meng, Jie ^{[1
,2
]}

Wang, Paul C. ^{[4
]}

Wu, Xiaochun ^{[3
]}

Liang, Xing-Jie ^{[1
,2
]}

机构：

[1] Natl Ctr Nanosci & Technol, Lab Nanomed & Nanosafety, Div Nanomed & Nanobiol, Beijing, Peoples R China

[2] Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[3] Natl Ctr Nanosci & Technol, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China

[4] Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA

来源：

NANOSCALE | 2013年 / 5卷 / 01期

关键词：

PHOTOTHERMAL THERAPY; CELLULAR UPTAKE; NANOPARTICLES; CANCER; TOXICITY; DELIVERY; CELLS; SIZE;

D O I：

10.1039/c2nr31877f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We investigated the penetration and thermotherapy efficiency of different surface coated gold nanorods (Au NRs) in multicellular tumor spheroids. The current data show that negatively charged Au NRs, other than positively charged Au NRs, can penetrate deep into the tumor spheroids and achieve a significant thermal therapeutic benefit.

引用

页码：143 / 146

页数：4

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