Molecular Signatures of the Three Stem Cell Lineages in Hydra and the Emergence of Stem Cell Function at the Base of Multicellularity

被引：103

作者：

Hemmrich, Georg ^{[1
]}

Khalturin, Konstantin ^{[1
]}

Boehm, Anna-Marei ^{[1
]}

Puchert, Malte ^{[1
,2
]}

Anton-Erxleben, Friederike ^{[1
]}

Wittlieb, Joerg ^{[1
]}

Klostermeier, Ulrich C. ^{[3
]}

Rosenstiel, Philip ^{[3
]}

Oberg, Hans-Heinrich ^{[2
]}

Domazet-Loso, Tomislav ^{[4
,5
]}

Sugimoto, Toshimi ^{[6
]}

Niwa, Hitoshi ^{[6
]}

Bosch, Thomas C. G. ^{[1
]}

机构：

[1] Univ Kiel, Inst Zool, D-24098 Kiel, Germany

[2] Univ Hosp Schleswig Holstein, Inst Immunol, Kiel, Germany

[3] Univ Hosp Schleswig Holstein, IKMB, Kiel, Germany

[4] Max Planck Inst Evolutionary Biol, Lab Evolutionary Genet, Plon, Germany

[5] Rudjer Boskovic Inst, Div Mol Biol, Lab Evolutionary Genet, Zagreb, Croatia

[6] RIKEN Ctr Dev Biol, Lab Pluripotent Stem Cell Studies, Kobe, Hyogo, Japan

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2012年 / 29卷 / 11期

关键词：

aging; adult stem cell; self-renewal; differentiation; evolution; JELLYFISH PODOCORYNE-CARNEA; EVOLUTIONARY ORIGIN; METAZOAN HYDRA; CYCLE KINETICS; SEA-ANEMONE; DIFFERENTIATION; COMPLEXITY; GENES; PLURIPOTENCY; CNIDARIANS;

D O I：

10.1093/molbev/mss134

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How distinct stem cell populations originate and whether there is a clear stem cell "genetic signature" remain poorly understood. Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position. In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage communication. Our data show that principal functions of stem cell genes, such as maintenance of stemness and control of stem cell self-renewal and differentiation, arose very early in metazoan evolution. They are corroborating the view that stem cell types shared common, multifunctional ancestors, which achieved complexity through a stepwise segregation of function in daughter cells.

引用

页码：3267 / 3280

页数：14

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