Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cells

被引：69

作者：

Yang, Xiaokui ^{[1
]}

Wang, Jiandong ^{[1
]}

Zhou, Ying ^{[1
]}

Wang, Yamei ^{[2
]}

Wang, Shuyu ^{[1
]}

Zhang, Weiyuan ^{[1
]}

机构：

[1] Capital Univ Med Sci, Beijing Obstet & Gynecol Hosp, Beijing 100026, Peoples R China

[2] Capital Med Univ, Inst Canc, Dept Biochem & Mol Biol, Beijing 100069, Peoples R China

来源：

CANCER LETTERS | 2012年 / 321卷 / 02期

关键词：

Hsp70; Bax; Mitochondria; Cisplatin-resistance; Ovarian cancer; APOPTOSIS-INDUCING FACTOR; CYTOCHROME-C; INHIBITS APOPTOSIS; BCL-2; FAMILY; DEATH; RESISTANCE; RELEASE; PROTEIN; P53; HEAT-SHOCK-PROTEIN-70;

D O I：

10.1016/j.canlet.2012.01.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cisplatin can induce apoptosis in ovarian cancer cells through the mitochondrial death pathway, and dysregulation of this pathway contributes to cisplatin resistance in ovarian cancer cells. Here we show that cisplatin induces mitochondrial proteins such as Smac/DIABLO, Cytochrome c, and HrtA2/Omi release to the cytosol and apoptosis in cisplatin-sensitive, but not -resistant ovarian cancer cells. Bax translocation to mitochondria is required for mitochondrial protein release and cisplatin-induced apoptosis in human ovarian cancer cells. Hsp70 is highly expressed in cisplatin-resistant cells. Hsp70 promotes chemoresistance, in part, by blocking Bax translocation to the mitochondria and mitochondrial protein release to cytosol in human ovarian cancer cells. (c) 2012 Published by Elsevier Ireland Ltd.

引用

页码：137 / 143

页数：7

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