In situ alkaline media: Synthesis, spectroscopic, morphology and anticancer assignments of some transition metal ion complexes of 1-((2-aminophenylimino) methyl) naphthalen-2-ol Schiff base

Four Schiff base complexes of Cu(II), Co(II), Ni(II) and Zn(II) metal ions were synthesized by reaction of 1-((2-aminophenylimino)methyl)naphthalen-2-ol (HL) with metal(II) chloride salts. The geometric structures of these complexes were elucidated based on different types of analyses like elemental analyses and spectroscopic instruments (FT-IR, UV-Vis., mass and H-1 NMR). Microanalytical analysis was confirmed the 1:1 stoichiometry ratio (metal: HL). The molar conductance values (3.80-5.59 mu S) referred that all HL complexes have an electrolytic behavior in comparable with free HL data (1.35 mu S) except for non-electrolytic copper(II) complex (1.46 mu S). The general formulas of the synthetic complexes were [M(L)(H2O)(3)](+)center dot CI-center dot 3H(2)O (M = Co2+& Ni2+), [Zn(L)(H2O)](-)center dot CI- and [Cu(L)(Cl)(H2O)(2)]. The assignments of FTIR spectra confirmed that the deprotonated HL Schiff base ligand acts as a tridentate NNO chelate through oxygen -O of phenolic group and both nitrogen atoms of -NH2 and C=N azomethine groups. The electronic, magnetic and electron spin resonance analyses revealed that all complexes are six coordinated but zinc(II) complex is four coordinated geometry. The thermogravimetric analyses (TGA/DTG) and differentially thermal analyses (DTA) of the free HL chelate and its complexes have been performed under N-2 atmosphere. The final thermal decomposition residue of metal-Schiff base complexes has been MO formula. The crystalline surface morphology of the solid products were investigated dependent on X-ray diffractometer and scanning electron microscopy. The efficiency of antimicrobial (bacteria & fungi) and anticancer of colon carcinoma HCT-116 cell lines were assessed against free HL Schiff base ligand and their four complexes. (C) 2019 Elsevier B.V. All rights reserved.