Synthesis and pharmacological activities of 3-(4-substituted phenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde and its aldimines derivatives

被引：0

作者：

Shetty, S. C. ^{[1
]}

Bhagat, V. C. ^{[1
]}

机构：

[1] Rajgad Dnyanpeeths Coll Pharm, Dept Pharmaceut Chem, Bhor 412206, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2008年 / 20卷 / 07期

关键词：

substituted pyrazoles; aldimines derivatives; analgesic; anxiolytic;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of heterocyclic compounds were achieved by the synthesis of 3-(4-substituted phenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde (IIHv) was synthesized from 4-substituted acetophenone phenylhydrazone (I-Hv) by Vilsmeier-Haack reaction compound (IIHv), was further functionalized by condensation. The reaction with various substituted anilines in refluxed ethanol with trace of cone. acetic acid to give corresponding aldimines derivatives(IIII-xIi).The synthesized compounds were screened of in vivo analgesic and anxiolytic activities in mice by acetic acid induced writhing test, elevated plus maze and light & dark exploration test in mice. The compound IIIVII, IIIIX and IIIXII showed very good anxiolytic activity, while compound no. IIIvi, IIIvii and IIIx showed very good analgesic activity.

引用

页码：5037 / 5045

页数：9

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