Subsequent Risks of Parkinson Disease in Patients with Autoimmune and Related Disorders: A Nationwide Epidemiological Study from Sweden

被引：82

作者：

Li, Xinjun ^{[1
]}

Sundquist, Jan ^{[2
]}

Sundquist, Kristina

机构：

[1] Lund Univ, Ctr Primary Hlth Care Res, CRC, SUS, SE-20502 Malmo, Sweden

[2] Stanford Univ, Sch Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA

来源：

NEURODEGENERATIVE DISEASES | 2012年 / 10卷 / 1-4期

关键词：

Autoimmune disorders; Subsequent Parkinson disease; Population-based study; Follow-up study; ANKYLOSING-SPONDYLITIS; HOSPITALIZATION; SCLEROSIS;

D O I：

10.1159/000333222

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: To investigate associations between autoimmune disorders and Parkinson disease (PD), and to study whether the risk is associated with follow-up time and age. Methods: Standardized incidence ratios (SIRs) were calculated for PD in patients with autoimmune disorders by comparing them to subjects without autoimmune disorders. Results: Among 310,522 patients with a total of 33 conditions of autoimmune disorders, 932 patients developed subsequent PD, giving an overall SIR of 1.33 and 1.19 for PD diagnosed later than 1 year after follow-up. Six types of autoimmune disorders showed an increased risk. These conditions included: amyotrophic lateral sclerosis, Graves's disease/hyperthyroidism, Hashimoto's disease/hypothyroidism, multiple sclerosis, pernicious anemia, and polymyalgia rheumatica. The risks depended on the age at hospitalization for PD. Conclusions: A 33% overall excess risk of PD was noted among patients with an autoimmune disorder; the risk was increased during the first 10 years of follow-up after hospitalization of autoimmune disorders. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：277 / 284

页数：8

共 20 条

[11] Reactive arthritis [J].

Leirisalo-Repo, M .

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2005, 34 (04) :251-259

[12] Beyond Parkinson Disease: Amyotrophic Lateral Sclerosis and the Axon Guidance Pathway [J].

Lesnick, Timothy G. ;

Sorenson, Eric J. ;

Ahlskog, J. Eric ;

Henley, John R. ;

Shehadeh, Lina ;

Papapetropoulos, Spiridon ;

Maraganore, Demetrius M. .

PLOS ONE, 2008, 3 (01)

[13] Impact of psychiatric disorders on Parkinson's disease [J].

Li, Xinjun ;

Sundquist, Jan ;

Hwang, Helen ;

Sundquist, Kristina .

JOURNAL OF NEUROLOGY, 2008, 255 (01) :31-36

[14] Socioeconomic and occupational groups and Parkinson's disease: a nationwide study based on hospitalizations in Sweden [J].

Li, Xinjun ;

Sundquist, Jan ;

Sundquist, Kristina .

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 2009, 82 (02) :235-241

[15]

Monahan AJ, 2008, CELL TRANSPLANT, V17, P363

[16] Parkinson's disease and thyroid dysfunction [J].

Munhoz, RP ;

Teive, HAG ;

Troiano, AR ;

Hauck, PR ;

Leiva, MHBH ;

Graff, H ;

Werneck, LC .

PARKINSONISM & RELATED DISORDERS, 2004, 10 (06) :381-383

[17] Autoimmune disease and risk for Parkinson disease A population-based case-control study [J].

Rugbjerg, K. ;

Friis, S. ;

Ritz, B. ;

Schernhammer, E. S. ;

Korbo, L. ;

Olsen, J. H. .

NEUROLOGY, 2009, 73 (18) :1462-1468

[18]

Socialstyrelsen, 1998, PAT 1987 1996 KVAL I

[19] Subsequent risk of hospitalization for neuropsychiatric disorders in patients with rheumatic diseases [J].

Sundquist, Kristina ;

Li, Xinjun ;

Hemminki, Kari ;

Sundquist, Jan .

ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (05) :501-507

[20] Familial risks of hospitalization for Parkinson's disease in first-degree relatives: a nationwide follow-up study from Sweden [J].

Sundquist, Kristina ;

Li, Xinjun ;

Hemminki, Kari .

NEUROGENETICS, 2006, 7 (04) :231-237

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