Erythrocyte sialic acid content during aging in humans: Correlation with markers of oxidative stress

被引:0
作者
Mehdi, Mohammad Murtaza [1 ]
Singh, Prabhakar [1 ]
Rizvi, Syed Ibrahim [1 ]
机构
[1] Univ Allahabad, Dept Biochem, Allahabad 211002, Uttar Pradesh, India
关键词
Erythrocyte; aging; sialic acid; oxidative stress; PLASMA-PROTEIN OXIDATION; MEMBRANE REDOX SYSTEM; LECTINS; HYDROPEROXIDES; PARAMETERS; DISEASE; SAMPLE; DAMAGE; BLOOD; RISK;
D O I
10.1155/2012/293429
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Sialic acids are substituted neuraminic acid derivatives which are typically found at the outermost end of glycan chains on the membrane in all cell types. The role of erythrocyte membrane sialic acids during aging has been established however the relationship between sialic acid and oxidative stress is not fully understood. The present work was undertaken to analyze the relationship between erythrocyte membrane sialic acid with its plasma level, membrane and plasma lipid hydroperoxide levels and plasma total antioxidant capacity. Results show that sialic acid content decreases significantly (P < 0.001) in RBC membrane (r = -0.901) and increases in plasma (r = 0.860) as a function of age in humans. Lipid peroxidation measured in the form of hydroperoxides increases significantly (P < 0.001) in plasma (r = 0.830) and RBC membranes (r = 0.875) with age in humans. The Trolox Equivalent Total Antioxidant Capacity (TETAC) of plasma was found to be significantly decreased (P < 0.001, r = -0.844). We observe significant correlations between decrease of erythrocyte membrane sialic acid and plasma lipid hydroperoxide and TETAC. Based on the observed correlations, we hypothesize that increase in oxidative stress during aging may influence the sialic acid decomposition from membrane thereby altering the membrane configuration affecting many enzymatic and transporter activities. Considering the importance of plasma sialic acid as a diagnostic parameter, it is important to establish age-dependent reference.
引用
收藏
页码:179 / 186
页数:8
相关论文
共 50 条
  • [41] A comparative study of serum protein-bound sialic acid in benign and malignant prostatic growth: possible role of oxidative stress in sialic acid homeostasis
    Goswami, K.
    Nandeesha, H.
    Koner, B. C.
    Nandakumar, D. N.
    PROSTATE CANCER AND PROSTATIC DISEASES, 2007, 10 (04) : 356 - 359
  • [42] A comparative study of serum protein-bound sialic acid in benign and malignant prostatic growth: possible role of oxidative stress in sialic acid homeostasis
    K Goswami
    H Nandeesha
    B C Koner
    D N Nandakumar
    Prostate Cancer and Prostatic Diseases, 2007, 10 : 356 - 359
  • [43] Correlation between oxidative stress markers and cytokines in different stages of breast cancer
    Ghafoor, Dlzar Dlshad
    CYTOKINE, 2023, 161
  • [44] Physical activity and oxidative stress during aging
    Polidori, MC
    Mecocci, P
    Cherubini, A
    Senin, U
    INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2000, 21 (03) : 154 - 157
  • [45] Sialic acid attenuates puromycin aminonucleoside-induced desialylation and oxidative stress in human podocytes
    Pawluczyk, Izabella Z. A.
    Najafabadi, Maryam Ghaderi
    Patel, Samita
    Desai, Priyanka
    Vashi, Dipti
    Saleem, Moin A.
    Topham, Peter S.
    EXPERIMENTAL CELL RESEARCH, 2014, 320 (02) : 258 - 268
  • [46] AN INVESTIGATION OF OXIDATIVE STRESS AND TOTAL SIALIC ACID LEVELS IN DOGS NATURALLY INFESTED WITH SARCOPTES CANIS
    Mor, Neriman
    Erkilic, Ekin Emre
    Kirmizigul, Ali Haydar
    Ogun, Metin
    Merhan, Oguz
    FRESENIUS ENVIRONMENTAL BULLETIN, 2019, 28 (11): : 8301 - 8306
  • [47] Ellagic Acid Displays a Protective Effect on Red Blood Cell Membrane During Aging in Humans
    Deepika
    Dakal, Tikam Chand
    Richa
    Maurya, Pawan Kumar
    INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY, 2024,
  • [48] Imidazole-Based Erythrocyte Markers of Oxidative Stress in Preeclampsia—An NMR Investigation
    Elizabeth Turner
    Jennifer A. Brewster
    Nigel A. B. Simpson
    James J. Walker
    Julie Fisher
    Reproductive Sciences, 2009, 16 : 1040 - 1051
  • [49] Oxidative stress in testis of animals during aging with and without reproductive activity
    Salomon, Tiago Boeira
    Hackenhaar, Fernanda Schaefer
    Almeida, Ana Carolina
    Schueller, Arthur Krumberg
    Gil Alabarse, Paulo V.
    Ehrenbrink, Guilherme
    Benfato, Mara Silveira
    EXPERIMENTAL GERONTOLOGY, 2013, 48 (09) : 940 - 946
  • [50] Decreased oxidative stress response and oxidant detoxification of skin during aging
    Dai, Xixia
    Hu, Yibo
    Jiang, Ling
    Lei, Li
    Fu, Chuhan
    Wu, Songjiang
    Zhang, Xiaolin
    Zhu, Lu
    Zhang, Fan
    Chen, Jing
    Zeng, Qinghai
    MECHANISMS OF AGEING AND DEVELOPMENT, 2023, 216