Signals for pre-mRNA cleavage and polyadenylation

被引：180

作者：

Tian, Bin ^{[1
]}

Graber, Joel H. ^{[2
]}

机构：

[1] UMDNJ New Jersey Med Sch, Newark, NJ 07103 USA

[2] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-RNA | 2012年 / 3卷 / 03期

关键词：

3' UNTRANSLATED REGIONS; LARGE-SCALE ANALYSIS; ALTERNATIVE POLYADENYLATION; DOWNSTREAM ELEMENTS; SEQUENCE ELEMENTS; 3'-END FORMATION; REGULATORY ELEMENTS; STIMULATION FACTOR; SPECIFICITY FACTOR; DISTINCT SEQUENCE;

D O I：

10.1002/wrna.116

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pre-mRNA cleavage and polyadenylation is an essential step for 3' end formation of almost all protein-coding transcripts in eukaryotes. The reaction, involving cleavage of nascent mRNA followed by addition of a polyadenylate or poly(A) tail, is controlled by cis-acting elements in the pre-mRNA surrounding the cleavage site. Experimental and bioinformatic studies in the past three decades have elucidated conserved and divergent elements across eukaryotes, from yeast to human. Here we review histories and current models of these elements in a broad range of species. (c) 2011 John Wiley & Sons, Ltd.

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页码：385 / 396

页数：12

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