The potential efficacy of GABAB antagonists in depression

被引：11

作者：

Alexander, Robert C. ^{[1
]}

机构：

[1] Takeda Pharmaceut Int Co, 40 Landsdowne St, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2017年 / 35卷

关键词：

RECEPTOR ANTAGONIST; FRONTAL-CORTEX; BINDING-SITES; ANTIDEPRESSANTS; RATS; ANXIETY; MODULATION; DISORDERS; BACLOFEN; DRUGS;

D O I：

10.1016/j.coph.2017.07.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Evidence for the potential utility of GABAB antagonists has been assembled from a variety of sources, including clinical experience with the GABAB agonist baclofen, murine genetic GABAB knock-outs, rodent studies of GABAB receptor expression and function following treatment with antidepressant therapies, animal models of depression, and some functional and post mortem data from human subjects. Definitive testing of GABAB antagonists in depression, however, still awaits the development of potent, selective and brain-penetrant compounds for human testing.

引用

页码：101 / 104

页数：4

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