Disaccharide synthesis on a soluble hyperbranched polymer

被引：30

作者：

Kantchev, AB ^{[1
]}

Parquette, JR ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 46期

关键词：

carbohydrates; oligosaccharides; hyperbranched polymer; solution-phase synthesis;

D O I：

10.1016/S0040-4039(99)01709-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A hyperbranched star polymer was employed as a soluble support for disaccharide synthesis as a practical alternative to a dendrimer support. The large number of terminal groups present on the support permit very high loading levels to be possible. Polymer bound intermediates could be directly analyzed by MALDI-TOF mass spectrometry due to the presence of a photolabile linker that is cleaved by the MALDI-TOF laser. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：8049 / 8053

页数：5

相关论文

共 23 条

[1] A reinvestigation of the preparation, properties, and applications of aminomethyl and 4-methylbenzhydrylamine polystyrene resins [J].

Adams, JH ;

Cook, RM ;

Hudson, D ;

Jammalamadaka, V ;

Lyttle, MH ;

Songster, MF .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (11) :3706-3716

[2] THE SYNTHESIS OF BETA-MANNOPYRANOSIDES BY INTRAMOLECULAR AGLYCON DELIVERY - SCOPE AND LIMITATIONS OF THE EXISTING METHODOLOGY [J].

BARRESI, F ;

HINDSGAUL, O .

CANADIAN JOURNAL OF CHEMISTRY, 1994, 72 (06) :1447-1465

[3] Synthesis of new poly(ethyleneglycol)s with a high loading capacity [J].

Benaglia, M ;

Annunziata, R ;

Cinquini, M ;

Cozzi, F ;

Ressel, S .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (24) :8628-8629

[4] DISPIROKETALS IN SYNTHESIS .5. A NEW OPPORTUNITY FOR OLIGOSACCHARIDE SYNTHESIS USING DIFFERENTIALLY ACTIVATED GLYCOSYL DONORS AND ACCEPTORS [J].

BOONS, GJ ;

GRICE, P ;

LESLIE, R ;

LEY, SV ;

YEUNG, LL .

TETRAHEDRON LETTERS, 1993, 34 (52) :8523-8526

[5]

Curran DP, 1998, ANGEW CHEM INT EDIT, V37, P1175, DOI 10.1002/(SICI)1521-3773(19980518)37:9<1174::AID-ANIE1174>3.0.CO

[6]

2-P

[7] POLYMER-SUPPORTED SOLUTION SYNTHESIS OF OLIGOSACCHARIDES USING A NOVEL VERSATILE LINKER FOR THE SYNTHESIS OF D-MANNOPENTAOSE, A STRUCTURAL UNIT OF D-MANNANS OF PATHOGENIC YEASTS [J].

DOUGLAS, SP ;

WHITFIELD, DM ;

KREPINSKY, JJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (07) :2116-2117

[8] Hyperbranched polyphenylene and hyperbranched polyesters: New soluble, three-dimensional, reactive polymers [J].

Frechet, JMJ ;

Hawker, CJ .

REACTIVE & FUNCTIONAL POLYMERS, 1995, 26 (1-3) :127-136

[9] Organic chemistry on solid supports [J].

Fruchtel, JS ;

Jung, G .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (01) :17-42

[10]

Garegg PJ, 1997, ADV CARBOHYD CHEM BI, V52, P179, DOI 10.1016/S0065-2318(08)60091-8