High-density lipoproteins, inflammation and oxidative stress

被引：135

作者：

Tabet, Fatiha ^{[1
]}

Rye, Kerry-Anne ^{[1
,2
,3
]}

机构：

[1] Heart Res Inst, Lipid Res Grp, Camperdown, NSW 2050, Australia

[2] Univ Sydney, Fac Med, Sydney, NSW 2006, Australia

[3] Univ Melbourne, Dept Med, Melbourne, Vic 3065, Australia

来源：

CLINICAL SCIENCE | 2009年 / 116卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

antioxidant; cholesterol; coronary heart disease; high-density lipoprotein (HDL); inflammation; APOLIPOPROTEIN-A-I; PHOSPHOLIPID TRANSFER PROTEIN; ADHESION MOLECULE EXPRESSION; REVERSE CHOLESTEROL TRANSPORT; CORONARY-ARTERY-DISEASE; ESTER TRANSFER PROTEIN; LIPOPOLYSACCHARIDE-BINDING PROTEIN; RANDOMIZED CONTROLLED-TRIAL; SUPEROXIDE ANION PRODUCTION; E-DEFICIENT MICE;

D O I：

10.1042/CS20080106

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Plasma levels of HDL (high-density lipoprotein)-cholesterol are strongly and inversely correlated with atherosclerotic cardiovascular disease. Both clinical and epidemiological studies have reported an inverse and independent association between serum HDL-cholesterol levels and CHD (coronary heart disease) risk. The cardioprotective effects of HDLs have been attributed to several mechanisms, including their involvement in the reverse cholesterol transport pathway. HDLs also have antioxidant, anti-inflammatory and antithrombotic properties and promote endothelial repair, all of which are likely to contribute to their ability to prevent CHD. The first part of this review summarizes what is known about the origins and metabolism of HDL. We then focus on the anti-inflammatory and antioxidant properties of HDL and discuss why these characteristics are cardioprotective.

引用

页码：87 / 98

页数：12

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