Type 1 Diabetes: Current Concepts in Epidemiology, Pathophysiology, Clinical Care, and Research

被引：88

作者：

Gan, Mary Joyce ^{[1
]}

Albanese-O'Neill, Anastasia ^{[1
]}

Haller, Michael J. ^{[1
]}

机构：

[1] Univ Florida, Dept Pediat, Gainesville, FL 32610 USA

来源：

CURRENT PROBLEMS IN PEDIATRIC AND ADOLESCENT HEALTH CARE | 2012年 / 42卷 / 10期

关键词：

STEM-CELL TRANSPLANTATION; PROGRESSIVE MULTIPLE-SCLEROSIS; GLUTAMIC-ACID DECARBOXYLASE; ANTI-THYMOCYTE GLOBULIN; C-PEPTIDE LEVELS; ISLET-CELL; ANTITHYMOCYTE GLOBULIN; FOLLOW-UP; IMMUNOSUPPRESSIVE THERAPY; CD3-ANTIBODY THERAPY;

D O I：

10.1016/j.cppeds.2012.07.002

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Type 1 diabetes (T1D) is an autoimmune disease mediated by a combination of genetic and environmental triggers resulting in lymphocytic infiltration of pancreatic islets, destruction of beta cells, and lifelong dependency on exogenous insulin. Although T1D is prevalent (1 in 300) and its incidence is steadily increasing worldwide (3% per year), the exact gene-environment interactions precipitating the disease remain unknown. Living with T1D is challenging for patients, families, and caregivers. Because of the relative paucity of pediatric endocrinologists, general pediatricians and other subspecialists may occasionally be faced with the task of managing diabetes-related complaints. Herein, we provide a comprehensive review of the natural history, pathophysiology, and contemporary management of T1D. In addition, recent advances in T1D research are discussed. Curr Probl Pediatr Adolesc Health Care 2012;42:269-291

引用

页码：269 / 291

页数：23

共 90 条

[1]

Akerblom HK, 1998, DIABETES METAB REV, V14, P31, DOI 10.1002/(SICI)1099-0895(199803)14:1<31::AID-

[2]

Amer Diabet Assoc, 2012, DIABETES CARE, V35, pS64, DOI [10.2337/dc19-S002, 10.2337/dc12-S064, 10.2337/dc23-S002, 10.2337/dc09-S062, 10.2337/dc18-S002]

[3]

ATKINSON M A, 1990, Journal of Autoimmunity, V3, P41

[4] INSULITIS AND DIABETES IN NOD MICE REDUCED BY PROPHYLACTIC INSULIN THERAPY [J].

ATKINSON, MA ;

MACLAREN, NK ;

LUCHETTA, R .

DIABETES, 1990, 39 (08) :933-937

[5] ARE INSULIN AUTOANTIBODIES MARKERS FOR INSULIN-DEPENDENT DIABETES-MELLITUS [J].

ATKINSON, MA ;

MACLAREN, NK ;

RILEY, WJ ;

WINTER, WE ;

FISK, DD ;

SPILLAR, RP .

DIABETES, 1986, 35 (08) :894-898

[6] Toward Closing the Loop: An Update on Insulin Pumps and Continuous Glucose Monitoring Systems [J].

Aye, Tandy ;

Block, Jen ;

Buckingham, Bruce .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2010, 39 (03) :609-+

[7] Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY) [J].

Barker, JM ;

Barriga, KJ ;

Yu, LP ;

Miao, DM ;

Erlich, HA ;

Norris, JM ;

Eisenbarth, GS ;

Rewers, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (08) :3896-3902

[8] Incidence and trends of childhood Type 1 diabetes worldwide 1990-1999 [J].

Bessaoud, K. ;

Boudraa, G. ;

Molinero de Ropolo, M. ;

de Sereday, M. ;

Marti, M. L. ;

Moser, M. ;

Lapertosa, S. ;

Damiano, M. ;

Verge, C. ;

Howard, N. ;

Schober, E. ;

Jordan, O. ;

Weets, I. ;

Gorus, F. ;

Coeckelberghs, M. ;

Rooman, R. ;

Van Gaal, L. ;

Franco, L. J. ;

Ferreira, S. R. G. ;

Lisboa, H. P. K. ;

Kurtz, L. A. ;

Graebin, R. ;

Kutzke, L. ;

Rodriges, C. ;

Savova, R. ;

Christov, V. ;

Iotova, V. ;

Tzaneva, V. ;

Pacaud, D. ;

Toth, E. ;

Tan, M. H. ;

Carrasco, E. ;

Perez, F. ;

Ze, Y. ;

Bo, Y. ;

Chen, S. ;

Fu, L. ;

Deng, L. ;

Shen, S. ;

Teng, K. ;

Wang, C. ;

Jian, H. ;

Ju, J. ;

Yan, C. ;

Ze, Y. ;

Deng, Y. ;

Li, C. ;

Zhang, Y. ;

Liu, Y. ;

Long, X. .

DIABETIC MEDICINE, 2006, 23 (08) :857-866

[9]

Bonifacio E, 2010, JDRF FUNDED RES PREP

[10]

Bougneres P F, 1987, Journ Annu Diabetol Hotel Dieu, P181

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