Magnetoencephalography in the study of epilepsy and consciousness

被引：11
作者：
Foley, Elaine [1 ]
Cerquiglini, Antonella [7 ]
Cavanna, Andrea [4 ,5 ,6 ]
Nakubulwa, Mable Angela [1 ]
Furlong, Paul Lawrence [1 ]
Witton, Caroline [1 ]
Seri, Stefano [1 ,2 ,3 ]
机构：
[1] Aston Univ, Aston Brain Ctr, Wellcome Trust Lab MEG Studies, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England
[2] Birmingham Childrens Hosp NHS Fdn Trust, Dept Clin Neurophysiol, Birmingham, W Midlands, England
[3] Birmingham Childrens Hosp NHS Fdn Trust, Pediat Epilepsy Surg Programme, Birmingham, W Midlands, England
[4] Univ Birmingham, Dept Neuropsychiat, Birmingham, W Midlands, England
[5] BSMHFT, Birmingham, W Midlands, England
[6] UCL, Inst Neurol, London, England
[7] Sapienza Univ Roma, Dev Neuropsychiat Unit, Dipartimento Sci & Biotecnol Med Chirurg, Polo Pontino, Italy
来源：
EPILEPSY & BEHAVIOR | 2014年 / 30卷
基金：
英国惠康基金; 英国工程与自然科学研究理事会;
关键词：
Magnetoencephalography; Epilepsy; Connectivity; Phase lag index; Absence seizures; FUNCTIONAL CONNECTIVITY; ABSENCE SEIZURES; RESTING-STATE; SLOW-WAVE; BRAIN; DISCHARGES; MEG; NETWORKS; EEG; SPIKE;
D O I：
10.1016/j.yebeh.2013.09.005
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The neural bases of altered consciousness in patients with epilepsy during seizures and at rest have raised significant interest in the last decade. This exponential growth has been supported by the parallel development of techniques and methods to investigate brain function noninvasively with unprecedented spatial and temporal resolution. In this article, we review the contribution of magnetoencephalography to deconvolve the bioelectrical changes associated with impaired consciousness during seizures. We use data collected from a patient with refractory absence seizures to discuss how spike-wave discharges are associated with perturbations in optimal connectivity within and between brain regions and discuss indirect evidence to suggest that this phenomenon might explain the cognitive deficits experienced during prolonged 3/s spike-wave discharges. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：38 / 42
页数：5
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