Steroidogenic factor-1 and endometriosis

被引：66

作者：

Bulun, Serdar E. ^{[1
]}

Utsunomiya, Hiroki ^{[1
,2
]}

Lin, Zhihong ^{[1
]}

Yin, Ping ^{[1
]}

Cheng, You-Hong ^{[1
]}

Pavone, Mary E. ^{[1
]}

Tokunaga, Hideki ^{[1
]}

Trukhacheva, Elena ^{[1
]}

Attar, Erkut ^{[1
,3
]}

Gurates, Bilgin ^{[3
]}

Milad, Magdy P. ^{[4
]}

Confino, Edmond ^{[4
]}

Su, Emily ^{[1
]}

Reierstad, Scott ^{[1
]}

Xue, Qing ^{[1
]}

机构：

[1] Northwestern Univ, Div Reprod Biol Res, Dept Obstet & Gynecol, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Tohoku Univ, Sch Med, Dept Obstet & Gynecol, Sendai, Miyagi 980, Japan

[3] Istanbul Univ, Capa Sch Med, Dept Obstet & Gynecol, Istanbul, Turkey

[4] Northwestern Univ, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2009年 / 300卷 / 1-2期

关键词：

Endometriosis; Steroidogenic factor-1; Aromatase; Estradiol; Prostaglandin E2; Estrogen biosynthesis; StAR; STROMAL CELLS; AROMATASE EXPRESSION; CYCLOOXYGENASE-2; EXPRESSION; EPITHELIAL-CELLS; P450; BREAST-CANCER; PROMOTER II; BINDING; GENE; TRANSCRIPTION;

D O I：

10.1016/j.mce.2008.12.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endometriosis is a common and chronic disease characterized by persistent pelvic pain and infertil, ity. Estradiol is essential for growth and inflammation in endometriotic tissue. The complete cascade of steroidogenic proteins/enzymes including aromatase is present in endometriosis leading to de novo estradiol synthesis. PGE(2) induces the expression of the genes that encode these enzymes. Upon PGE(2) treatment, coordinate recruitment of the nuclear receptor SF-1 to the promoters of these steroidogenic genes is the key event for estradiol synthesis. SF-1 is the key factor determining that an endometriotic cell will respond to PGE(2) by increased estradiol formation. The presence of SF-1 in endometriosis and its absence in endometrium is determined primarily by the methylation of its promoter. The key steroidogenic enzyme in endometriosis is aromatase encoded by a single gene because its inhibition blocks all estradiol biosynthesis. Aromatase inhibitors diminish endometriotic implants and associated pain refractory to existing treatments in affected women. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：104 / 108

页数：5

共 27 条

[21] Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells [J].