Screening for Pancreatic Cancer

被引：17

作者：

Ngamruengphong, Saowanee ^{[1
]}

Canto, Marcia Irene ^{[1
]}

机构：

[1] Johns Hopkins Univ Hosp, Johns Hopkins Med Inst, Div Gastroenterol & Hepatol, Blalock 407, Baltimore, MD 21287 USA

来源：

SURGICAL CLINICS OF NORTH AMERICA | 2016年 / 96卷 / 06期

关键词：

Familial pancreatic cancer; Pancreatic cancer; Pancreatic cyst; Pancreatic intraepithelial neoplasia; Intraductal papillary mucinous neoplasm; Screening; GENE-ENVIRONMENT INTERACTION; PEUTZ-JEGHERS-SYNDROME; HIGH-RISK INDIVIDUALS; HEREDITARY PANCREATITIS; FAMILY-HISTORY; CONSENSUS GUIDELINES; GERMLINE MUTATIONS; BRCA2; MUTATIONS; FOLLOW-UP; EUS;

D O I：

10.1016/j.suc.2016.07.016

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Pancreatic cancer (PC) is a highly fatal disease that can only be cured by complete surgical resection. However, most patients with PC have unresectable disease at the time of diagnosis, highlighting the need to detect PC and its precursor lesions earlier in asymptomatic patients. Screening is not cost-effective for population-based screening of PC. Individuals with genetic risk factors for PC based on family history or known PC associated genetic syndromes, however, can be a potential target for PC screening programs. This article provides an overview of the epidemiology and genetic background of familial PC and discusses diagnostic and management approaches.

引用

页码：1223 / +

页数：12

共 74 条

[1] Screening for Pancreatic Cancer in a High-Risk Cohort: An Eight-Year Experience [J].

Al-Sukhni, Wigdan ;

Borgida, Ayelet ;

Rothenmund, Heidi ;

Holter, Spring ;

Semotiuk, Kara ;

Grant, Robert ;

Wilson, Stephanie ;

Moore, Malcolm ;

Narod, Steven ;

Jhaveri, Kartik ;

Haider, Masoom A. ;

Gallinger, Steven .

JOURNAL OF GASTROINTESTINAL SURGERY, 2012, 16 (04) :771-783

[2] Analysis of PALB2 Gene in BRCA1/BRCA2 Negative Spanish Hereditary Breast/Ovarian Cancer Families with Pancreatic Cancer Cases [J].

Blanco, Ana ;

de la Hoya, Miguel ;

Osorio, Ana ;

Diez, Orland ;

Dolores Miramar, Maria ;

Infante, Mar ;

Martinez-Bouzas, Cristina ;

Torres, Asuncion ;

Lasa, Adriana ;

Llort, Gemma ;

Brunet, Joan ;

Grana, Begona ;

Perez Segura, Pedro ;

Jose Garcia, Maria ;

Gutierrez-Enriquez, Sara ;

Carracedo, Angel ;

Tejada, Maria-Isabel ;

Velasco, Eladio A. ;

Calvo, Maria-Teresa ;

Balmana, Judith ;

Benitez, Javier ;

Caldes, Trinidad ;

Vega, Ana .

PLOS ONE, 2013, 8 (07)

[3]

Breast Canc Linkage Consortium, 1999, JNCI-J NATL CANCER I, V91, P1310

[4]

Brentnall TA, 1999, ANN INTERN MED, V131, P247, DOI 10.7326/0003-4819-131-4-199908170-00003

[5] Pancreatic Cancer Surveillance: Learning As We Go [J].

Brentnall, Teresa A. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2011, 106 (05) :955-956

[6] Genetic and Epigenetic Alterations of Familial Pancreatic Cancers [J].

Brune, Kieran ;

Hong, Seung-Mo ;

Li, Ang ;

Yachida, Shinichi ;

Abe, Tadayoshi ;

Griffith, Margaret ;

Yang, Dawei ;

Omura, Noriyuki ;

Eshleman, James ;

Canto, Marcia ;

Schulick, Rich ;

Klein, Alison P. ;

Hruban, Ralph H. ;

Iacobuzio-Donohue, Christine ;

Goggins, Michael .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (12) :3536-3542

[7] Screening for early pancreatic neoplasia in high-risk individuals: A prospective controlled study [J].

Canto, Marcia Irene ;

Goggins, Michael ;

Hruban, Ralph H. ;

Petersen, Gloria M. ;

Giardiello, Francis M. ;

Yeo, Charles ;

Fishman, Elliott K. ;

Brune, Kieran ;

Axilbund, Jennifer ;

Griffin, Constance ;

Ali, Syed ;

Richman, Jeffrey ;

Jagannath, Sanjay ;

Kantsevoy, Sergey V. ;

Kalloo, Anthony N. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2006, 4 (06) :766-781

[8] Screening for Pancreatic Neoplasia in High-Risk Individuals: An EUS-Based Approach [J].

Canto, Marcia Irene ;

Goggins, Michael ;

Yeo, Charles J. ;

Griffin, Constance ;

Axilbund, Jennifer E. ;

Brune, Kieran ;

Ali, Syed Z. ;

Jagannath, Sanjay ;

Petersen, Gloria M. ;

Fishman, Elliot K. ;

Piantadosi, Steven ;

Giardiello, Francis M. ;

Hruban, Ralph H. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2004, 2 (07) :606-621

[9] International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer [J].

Canto, Marcia Irene ;

Harinck, Femme ;

Hruban, Ralph H. ;

Offerhaus, George Johan ;

Poley, Jan-Werner ;

Kamel, Ihab ;

Nio, Yung ;

Schulick, Richard S. ;

Bassi, Claudio ;

Kluijt, Irma ;

Levy, Michael J. ;

Chak, Amitabh ;

Fockens, Paul ;

Goggins, Michael ;

Bruno, Marco .

GUT, 2013, 62 (03) :339-347

[10] Frequent Detection of Pancreatic Lesions in Asymptomatic High-Risk Individuals [J].

Canto, Marcia Irene ;

Hruban, Ralph H. ;

Fishman, Elliot K. ;

Kamel, Ihab R. ;

Schulick, Richard ;

Zhang, Zhe ;

Topazian, Mark ;

Takahashi, Naoki ;

Fletcher, Joel ;

Petersen, Gloria ;

Klein, Alison P. ;

Axilbund, Jennifer ;

Griffin, Constance ;

Syngal, Sapna ;

Saltzman, John R. ;

Mortele, Koenraad J. ;

Lee, Jeffrey ;

Tamm, Eric ;

Vikram, Raghunandan ;

Bhosale, Priya ;

Margolis, Daniel ;

Farrell, James ;

Goggins, Michael .

GASTROENTEROLOGY, 2012, 142 (04) :796-804

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