Non-coding RNAs as therapeutic targets for preventing myocardial ischemia-reperfusion injury

被引：106

作者：

Ong, Sang-Bing ^{[1
]}

Katwadi, Khairunnisa ^{[1
]}

Kwek, Xiu-Yi ^{[1
]}

Ismail, Nur Izzah ^{[1
,2
]}

Chinda, Kroekkiat ^{[3
,4
]}

Ong, Sang-Ging ^{[5
]}

Hausenloy, Derek J. ^{[1
,6
,7
,8
]}

机构：

[1] Duke Natl Univ Singapore, Med Sch, Signature Res Program Cardiovasc & Metab Disorder, 8 Coll Rd, Singapore 169857, Singapore

[2] Univ Malaya, Dept Biomed Engn, Fac Engn, Kuala Lumpur, Malaysia

[3] Naresuan Univ, Dept Physiol, Fac Med Sci, Phitsanulok, Thailand

[4] Naresuan Univ, BRUCS, Phitsanulok, Thailand

[5] Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA USA

[6] Natl Heart Res Inst Singapore, Natl Heart CentreSingapore, Singapore, Singapore

[7] UCL, Inst Cardiovasc Sci, Hatter Cardiovasc Inst, London, England

[8] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2018年 / 22卷 / 03期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

Ischemia-reperfusion injury; long non-coding RNA; microRNAs; non-coding RNAs; acute myocardial infarction; cardioprotection; ischemic conditioning; INDUCED CARDIOMYOCYTE APOPTOSIS; HYPOXIA-INDUCED APOPTOSIS; CARDIAC ISCHEMIA/REPERFUSION INJURY; PRESERVES MITOCHONDRIAL-FUNCTION; REGULATES PROGRAMMED NECROSIS; PERMEABILITY TRANSITION PORE; DOWN-REGULATION; PROTECTS CARDIOMYOCYTES; CIRCULATING MICRORNAS; UP-REGULATION;

D O I：

10.1080/14728222.2018.1439015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: New treatments are required to improve clinical outcomes in patients with acute myocardial infarction (AMI), for reduction of myocardial infarct (MI) size and preventing heart failure. Following AMI, acute ischemia/reperfusion injury (IRI) ensues, resulting in cardiomyocyte death and impaired cardiac function. Emerging studies have implicated a fundamental role for non-coding RNAs (microRNAs [miRNA], and more recently long non-coding RNAs [lncRNA]) in the setting of acute myocardial IRI. Areas covered: In this article, we discuss the roles of miRNAs and lncRNAs as potential biomarkers and therapeutic targets for the detection and treatment of AMI, review their roles as mediators and effectors of cardioprotection, particularly in the settings of interventions such as ischemic pre- and post-conditioning (IPC & IPost) as well as remote ischemic conditioning (RIC), and highlight future strategies for targeting ncRNAs to reduce MI size and prevent heart failure following AMI. Expert opinion: Investigating the roles of miRNAs and lncRNAs in the setting of AMI has provided new insights into the pathophysiology underlying acute myocardial IRI, and has identified novel biomarkers and therapeutic targets for detecting and treating AMI. Pharmacological and genetic manipulation of these ncRNAs has the therapeutic potential to improve clinical outcomes in AMI patients.

引用

页码：247 / 261

页数：15