Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery

被引：34
|
作者：
Gerrard, J. A. [1 ]
Hutton, C. A. [2 ]
Perugini, M. A. [3 ]
机构：
[1] Univ Canterbury, Sch Biol Sci, Christchurch 1, New Zealand
[2] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Sch Chem, Melbourne, Vic 3010, Australia
[3] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Dept Biochem & Mol Biol, Melbourne, Vic 3010, Australia
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 02期
关键词：
Protein-protein interactions; inhibitor; amyloid; HIV; drug design; small molecule-protein interaction;
D O I：
10.2174/138955707779802561
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Association of proteins into homo- and hetero-oligomers plays an important role in a plethora of biological phenomena. Inhibition of these interactions is increasingly recognized as a valuable new direction in drug design. In this mini-review we consider inhibition of protein misfolding and aggregation, molecules that disrupt enzyme quaternary structure, and signaling inhibitors, as emerging drugs.
引用
收藏
页码：151 / 157
页数：7
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