Fast reductive ligation of S-nitrosothiols

被引：71

作者：

Wang, Hua ^{[1
]}

Xian, Ming ^{[1
]}

机构：

[1] Washington State Univ, Dept Chem, Pullman, WA 99164 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 35期

关键词：

nitrenes; nitrogen oxides; reductive ligation; S-nitrosothiols;

D O I：

10.1002/anie.200801654

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) "Nitroso" knows: A process has been developed which converts unstable S-nitrosothiols into stable sulfenamide analogues (see scheme).Reductive ligation proceeds rapidly in mixed organic solvent/water systems to give high yields. By applying this reaction, an efficient strategy for detecting S-nitrosylation in proteins and other biological systems is envisioned. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6598 / 6601

页数：4

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