Decreased level of peripheral CD8+CD28+T cells is associated with lymph node metastasis in patients with breast cancer

被引：5
作者：
Li, Yalun [1 ]
Qian, Tianyi [2 ,3 ]
Zhao, Hengqiang [4 ]
Zhang, Zhen [3 ,4 ]
Ming, Yue [5 ]
Qiao, Guangdong [1 ]
Liu, Jiaqi [2 ,6 ,7 ]
机构：
[1] Qingdao Univ, Dept Breast Surg, Affiliated Yantai Yuhuangding Hosp, Yantai 264000, Shandong, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Dept Breast Surg Oncol, Natl Canc Ctr,Natl Clin Res Ctr Canc, Beijing 100021, Peoples R China
[3] Chinese Acad Med Sci, Peking Union Med Coll, Beijing 100005, Peoples R China
[4] Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing 100730, Peoples R China
[5] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, PET CT Ctr, Natl Canc Ctr,Natl Clin Res Ctr Canc, Beijing 100021, Peoples R China
[6] Beijing Key Lab Genet Res Skeletal Deform, Beijing 100730, Peoples R China
[7] Wenzhou Med Univ, Inst Biomed Big Data, Wenzhou 325027, Peoples R China
来源：
FUTURE ONCOLOGY | 2020年 / 16卷 / 32期
基金：
中国国家自然科学基金;
关键词：
breast cancer; CD28; lymph node metastasis; lymphocyte subtypes; CD28; POLYMORPHISM; LYMPHOCYTES; GUIDELINES; SURVIVAL; THERAPY;
D O I：
10.2217/fon-2020-0614
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background:Lymph node metastasis (LNM) is an independent risk factor for prognosis in patients with early breast cancer (EBC). Here we explored whether peripheral lymphocyte subtypes could be used as surrogate markers for LNM in patients with EBC.Materials & methods:The lymphocyte subpopulations in peripheral blood were measured in 152 EBC patients and 43 patients with benign breast tumors.Results:The cytotoxic T cell count was significantly lower in patients with EBC than in patients with benign tumors (244.17 +/- 105.83 vs 289.97 +/- 121.72; p = 0.02), especially in patients with LNM (218.36 +/- 86.21; p = 0.04).Conclusion:A decreased level of peripheral CD8(+)CD28(+)T lymphocytes is associated with LNM in patients with EBC and could be used as a potential therapeutic target for breast cancer.
引用
收藏
页码：2611 / 2617
页数：7
相关论文
共 27 条
[1]   Estimating the benefits of therapy for early-stage breast cancer: the St. Gallen International Consensus Guidelines for the primary therapy of early breast cancer 2019 [J].
Burstein, H. J. ;
Curigliano, G. ;
Loibl, S. ;
Dubsky, P. ;
Gnant, M. ;
Poortmans, P. ;
Colleoni, M. ;
Denkert, C. ;
Piccart-Gebhart, M. ;
Regan, M. ;
Senn, H. -J. ;
Winer, E. P. ;
Thurlimann, B. .
ANNALS OF ONCOLOGY, 2019, 30 (10) :1541-1557
[2]  
CARTER CL, 1989, CANCER-AM CANCER SOC, V63, P181, DOI 10.1002/1097-0142(19890101)63:1<181::AID-CNCR2820630129>3.0.CO
[3]  
2-H
[4]   Systemic inflammation as a confounding factor in cancer biomarker discovery and validation [J].
Chechlinska, Magdalena ;
Kowalewska, Magdalena ;
Nowak, Radoslawa .
NATURE REVIEWS CANCER, 2010, 10 (01) :2-U13
[5]   Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity [J].
Chen, LP .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (05) :336-347
[6]  
Frauwirth KA, 2002, J CLIN INVEST, V109, P295, DOI 10.1172/JCI200214941
[7]   Axillary dissection versus no axillary dissection in patients with breast cancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised, controlled, phase 3 trial [J].
Galimberti, Viviana ;
Cole, Bernard F. ;
Viale, Giuseppe ;
Veronesi, Paolo ;
Vicini, Elisa ;
Intra, Mattia ;
Mazzarol, Giovanni ;
Massarut, Samuele ;
Zgajnar, Janez ;
Taffurelli, Mario ;
Littlejohn, David ;
Knauer, Michael ;
Tondini, Carlo ;
Di Leo, Angelo ;
Colleoni, Marco ;
Regan, Meredith M. ;
Coates, Alan S. ;
Gelber, Richard D. ;
Goldhirsch, Aron .
LANCET ONCOLOGY, 2018, 19 (10) :1385-1393
[8]   Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis The ACOSOG Z0011 (Alliance) Randomized Clinical Trial [J].
Giuliano, Armando E. ;
Ballman, Karla V. ;
McCall, Linda ;
Beitsch, Peter D. ;
Brennan, Meghan B. ;
Kelemen, Pond R. ;
Ollila, David W. ;
Hansen, Nora M. ;
Whitworth, Pat W. ;
Blumencranz, Peter W. ;
Leitch, A. Marilyn ;
Saha, Sukamal ;
Hunt, Kelly K. ;
Morrow, Monica .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 318 (10) :918-926
[9]   Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG [J].
Gu, Yan ;
Liu, Yanfang ;
Fu, Li ;
Zhai, Lili ;
Zhu, Jie ;
Han, Yanmei ;
Jiang, Yingming ;
Zhang, Yi ;
Zhang, Peng ;
Jiang, Zhengping ;
Zhang, Xiang ;
Cao, Xuetao .
NATURE MEDICINE, 2019, 25 (02) :312-+
[10]   Hallmarks of Cancer: The Next Generation [J].
Hanahan, Douglas ;
Weinberg, Robert A. .
CELL, 2011, 144 (05) :646-674
123