Development of a Lorentz-force Actuated Intravitreal Jet Injector

被引：0

作者：

White, James E. ^{[1
]}

Chang, Jean H. ^{[1
]}

Hogan, N. Catherine ^{[1
]}

Hunter, Ian W. ^{[1
]}

机构：

[1] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

来源：

2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2012年

关键词：

BEVACIZUMAB; NEEDLES;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Intravitreal injection is a common treatment in ophthalmology, but it can lead to numerous complications. Needle-free jet injection has been shown to successfully deliver fluid to various layers of skin, and, by its nature, may reduce intravitreal injection complications. From injection trials into ex vivo rabbit eyes, we find that needle-free jet injection can be used for intravitreal drug delivery. A custom-designed control scheme, characterized in this study, is crucial to this delivery. The system is capable of delivering 40 mu L of fluid to the posterior vitreous humor, with an injection duration less than 100 ms and scleral entry site less than 350 mu m in diameter.

引用

页码：984 / 987

页数：4