Acute Kidney Injury and Sepsis

被引：91

作者：

Skube, Steven J. ^{[1
]}

Katz, Stephen A. ^{[2
]}

Chipman, Jeffrey G. ^{[1
]}

Tignanelli, Christopher J. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Surg, Mayo Mail Code 195,420 Delaware St SE, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Integrat Biol & Physiol, Minneapolis, MN USA

来源：

SURGICAL INFECTIONS | 2018年 / 19卷 / 02期

关键词：

acute renal failure; renal; sepsis; CRITICALLY-ILL PATIENTS; ACUTE-RENAL-FAILURE; CAMPAIGN INTERNATIONAL GUIDELINES; PREDICT FLUID RESPONSIVENESS; LOW-EFFICIENCY DIALYSIS; INTENSIVE-CARE-UNIT; SEPTIC SHOCK; REPLACEMENT THERAPY; CYSTATIN-C; BLOOD-FLOW;

D O I：

10.1089/sur.2017.261

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Worldwide, both acute kidney injury (AKI) and sepsis are significant clinical complications, particularly in critical care patients. Sepsis is an important cause of AKI, and AKI is a common complication of sepsis. Methods: We reviewed the literature, including current practice guidelines, on sepsis-associated AKI. Results: We assessed causes of renal failure, potential mechanisms of sepsis-associated acute kidney injury, current practice guidelines, diagnostic criteria and methods, prevention strategies, treatment options, and outcomes. Conclusion: In patients with sepsis-associated AKI, appropriate fluid resuscitation and maintenance of blood pressure are important to prevent further kidney damage. Despite multiple clinical trials, the mechanisms of sepsis-associated AKI and the best treatment options remain unclear.

引用

页码：216 / 224

页数：9

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