A Critical Role of GIT1 in Vertebrate and Invertebrate Brain Development

被引：26

作者：

Hong, Sung-Tae ^{[1
]}

Mah, Won ^{[1
,2
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejeon, South Korea

[2] Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu, South Korea

来源：

EXPERIMENTAL NEUROBIOLOGY | 2015年 / 24卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

GIT1; dGit; Microcephaly; Brain Development; INTERACTING PROTEIN-1; SPINE MORPHOGENESIS; SYNAPSE FORMATION; DROSOPHILA; FAMILY;

D O I：

10.5607/en.2015.24.1.8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

GIT1, a multifunctional signaling adaptor protein, is implicated in the development of dendritic spines and neuronal synapses. GIT1 forms a signaling complex with PIX, RAC, and PAK proteins that is known to play important roles in brain development. Here we found that Git1-knockout (Git1(-/-)) mice show a microcephaly-like small brain phenotype, which appears to be caused by reduced neuronal size rather than number. Git1(-/-) mice also show decreased dendritic spine number without morphological alterations in the hippocampus. Behaviorally, Git1(-/-) mice show impaired motor coordination and learning and memory. In addition, adult dGit Drosophila mutants show decreased brain size and abnormal morphology of the mushroom body. These results suggest that GIT1 is important for brain development in both rodents and flies.

引用

页码：8 / 16

页数：9

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