Thiol-Mediated Anchoring of Silver Cations to DNA for Construction of Nanofibers on DNA Scaffold

被引：2

作者：

Zinchenko, Anatoly A. ^{[1
]}

Chen, Ning ^{[1
]}

Baigl, Damien ^{[2
,5
,6
]}

Lopatina, Larisa I. ^{[4
]}

Sergeyev, Vladimir G. ^{[3
]}

机构：

[1] Nagoya Univ, Grad Sch Environm Studies, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[2] Ecole Normale Super, Dept Chem, F-75005 Paris, France

[3] Moscow MV Lomonosov State Univ, Fac Chem, Dept Polymer Sci, Moscow 119899, Russia

[4] Moscow MV Lomonosov State Univ, Fac Chem, Dept Colloid Sci, Moscow 119899, Russia

[5] Univ Paris 06, F-75005 Paris, France

[6] CNRS, UMR 8640, Paris, France

来源：

BIOMACROMOLECULES | 2012年 / 13卷 / 06期

关键词：

COORDINATION POLYMERS; MAGNETIC NANOWIRES; LAYERED STRUCTURE; COMPLEXES; METALLIZATION; SPECTROSCOPY; BEHAVIOR; LIGANDS; CHAIN;

D O I：

10.1021/bm300277f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The formation of metal-containing Ag-mercaptoethanol (-Ag-S(R)-)(n) complexes on DNA chain scaffold was studied by UV spectroscopy, zeta potential measurement, and fluorescence and transmission electron microscopies. Experimental results made clear the mechanism of DNA mineralization and compaction, according to which intercalation of silver cations into DNA scaffold and further formation of (-Ag-S(R)-)(n) oligomeric complexes on DNA induce efficient DNA chain compaction by terminal Ag+ cations. By transmission electron microscopy the formation of fiber-like DNA-templated nanostructures was observed. DNA-Ag-thiol complexes are promising for DNA-templated engineering of hybrid ID nanostructures with adjustable chemical functionalities by choosing appropriate thiol ligand.

引用

页码：1787 / 1793

页数：7