Deltamethrin-induced alteration of iron metabolism in Wistar rats

被引：4
|
作者：
Abbas, Afshan Syed [1 ]
Manzoor, Farkhanda [1 ]
Shahzad, Kiran [1 ]
Sheikh, Nadeem [2 ]
Tanveer, Mehwish [1 ]
机构：
[1] Lahore Coll Women Univ, Dept Zool, Lahore 54000, Pakistan
[2] Univ Punjab, Dept Zool, Lahore, Pakistan
来源：
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | 2018年 / 100卷 / 5-7期
关键词：
Pesticides; deltamethrin; pyrethroid; iron; hepcidin; ferroportin; transferrin; LIPID-PEROXIDATION; HEPCIDIN; LIVER; CHLORPYRIFOS; EXPRESSION; EXPOSURE;
D O I：
10.1080/02772248.2018.1545908
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The impact of sub-lethal exposure to deltamethrin on the expression of hepcidin, ferroportin and transferrin genes in Wistar rats was studied. A dosage of 30mg/kg per day for five days was found to modify the hepcidin-ferroportin axis that primarily governs iron homeostasis. Significant variations in erythrocyte, leukocyte, lymphocyte, platelet and monocyte counts, as well as the reduced serum protein profile, suggested anemia. The results collectively demonstrated the novel finding of deltamethrin's disruptive effect on iron homeostasis.
引用
收藏
页码：601 / 606
页数：6
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