Melatonin down-regulates hTERT expression induced by either natural estrogens (17β-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells

被引：61

作者：

Martinez-Campa, Carlos M. ^{[1
]}

Alonso-Gonzalez, Carolina ^{[1
]}

Mediavilla, Maria D. ^{[1
]}

Cos, Samuel ^{[1
]}

Gonzalez, Alicia ^{[1
]}

Sanchez-Barcelo, Emilio J. ^{[1
]}

机构：

[1] Univ Cantabria, Sch Med, Dept Physiol & Pharmacol, Santander 39011, Spain

来源：

CANCER LETTERS | 2008年 / 268卷 / 02期

关键词：

hTERT; estradiol; cadmium; melatonin; MCF-7; cells;

D O I：

10.1016/j.canlet.2008.04.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The goal was to evaluate whether melatonin (Mel) down-regulates hTERT expression induced by 17 beta-estradiol (E-2) or cadmium (Cd) in breast cancer cells. We found that: (a) Mel inhibits E-2 or Cd-induced hTERT transcription in hTERT-Luc transfected MCF-7 cells, (b) Mel significantly reduces E-2- and Cd-mediated hTERT transactivation triggered by ER alpha in transfected HeLa cells, (c) Mel inhibits hTERT expression induced by E-2 or Cd in MCF-7 cells. Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors or carcinogenesis by environmental or occupational exposure to xenoestrogens. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：272 / 277

页数：6

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