Melatonin down-regulates hTERT expression induced by either natural estrogens (17β-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells

被引：59
作者：
Martinez-Campa, Carlos M. [1 ]
Alonso-Gonzalez, Carolina [1 ]
Mediavilla, Maria D. [1 ]
Cos, Samuel [1 ]
Gonzalez, Alicia [1 ]
Sanchez-Barcelo, Emilio J. [1 ]
机构：
[1] Univ Cantabria, Sch Med, Dept Physiol & Pharmacol, Santander 39011, Spain
来源：
CANCER LETTERS | 2008年 / 268卷 / 02期
关键词：
hTERT; estradiol; cadmium; melatonin; MCF-7; cells;
D O I：
10.1016/j.canlet.2008.04.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The goal was to evaluate whether melatonin (Mel) down-regulates hTERT expression induced by 17 beta-estradiol (E-2) or cadmium (Cd) in breast cancer cells. We found that: (a) Mel inhibits E-2 or Cd-induced hTERT transcription in hTERT-Luc transfected MCF-7 cells, (b) Mel significantly reduces E-2- and Cd-mediated hTERT transactivation triggered by ER alpha in transfected HeLa cells, (c) Mel inhibits hTERT expression induced by E-2 or Cd in MCF-7 cells. Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors or carcinogenesis by environmental or occupational exposure to xenoestrogens. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：272 / 277
页数：6
相关论文
共 28 条
  • [1] Melatonin prevents the estrogenic effects of sub-chronic administration of cadmium on mice mammary glands and uterus
    Alonso-Gonzalez, C.
    Gonzalez, A.
    Mazarrasa, O.
    Guezmes, A.
    Sanchez-Mateos, S.
    Martinez-Campa, C.
    Cos, S.
    Sanchez-Barcelo, E. J.
    Mediavilla, M. D.
    [J]. JOURNAL OF PINEAL RESEARCH, 2007, 42 (04) : 403 - 410
  • [2] Hormones and growth factors regulate telomerase activity in ageing and cancer
    Bayne, S
    Liu, JP
    [J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2005, 240 (1-2) : 11 - 22
  • [3] Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3
    Bilsland, AE
    Stevenson, K
    Atkinson, S
    Kolch, W
    Keith, WN
    [J]. CANCER RESEARCH, 2006, 66 (03) : 1363 - 1370
  • [4] Cos S, 1998, CANCER RES, V58, P4383
  • [5] Melatonin, an endogenous-specific inhibitor of estrogen receptor α via calmodulin
    del Río, B
    Pedrero, JMG
    Martínez-Campa, C
    Zuazua, P
    Lazo, PS
    Ramos, S
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (37) : 38294 - 38302
  • [6] GARCIAMORALES P, 1994, J BIOL CHEM, V269, P16896
  • [7] The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes
    Glasspool, RM
    Burns, S
    Hoare, SF
    Svensson, C
    Keith, WN
    [J]. NEOPLASIA, 2005, 7 (06): : 614 - 622
  • [8] Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland
    Johnson, MD
    Kenney, N
    Stoica, A
    Hilakivi-Clarke, L
    Singh, B
    Chepko, G
    Clarke, R
    Sholler, PF
    Lirio, AA
    Foss, C
    Reiter, R
    Trock, B
    Paik, S
    Martin, MB
    [J]. NATURE MEDICINE, 2003, 9 (08) : 1081 - 1084
  • [9] Raloxifene inhibits estrogen-induced up-regulation of telomerase activity in a human breast cancer cell line
    Kawagoe, J
    Ohmichi, M
    Takahashi, T
    Ohshima, C
    Mabuchi, S
    Takahashi, K
    Igarashi, H
    Mori-Abe, A
    Saitoh, M
    Du, BT
    Ohta, T
    Kimura, A
    Kyo, S
    Inoue, M
    Kurachi, H
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (44) : 43363 - 43372
  • [10] HTERT mRNA expression correlates with telomerase activity in human breast cancer
    Kirkpatrick, KL
    Clark, G
    Ghilchick, M
    Newbold, RF
    Mokbel, K
    [J]. EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 2003, 29 (04): : 321 - 326
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