Combined brain voxel-based morphometry and diffusion tensor imaging study in idiopathic Restless Legs Syndrome patients

被引：38

作者：

Rizzo, G. ^{[1
,2
]}

Manners, D. ^{[1
,3
]}

Vetrugno, R. ^{[2
]}

Tonon, C. ^{[1
]}

Malucelli, E. ^{[1
]}

Plazzi, G. ^{[2
]}

Marconi, S. ^{[2
]}

Pizza, F. ^{[2
]}

Testa, C. ^{[1
]}

Provini, F. ^{[2
]}

Montagna, P. ^{[2
]}

Lodi, R. ^{[1
]}

机构：

[1] Univ Bologna, Funct MR Unit, Dept Internal Med Aging & Nephrol, I-40138 Bologna, Italy

[2] Univ Bologna, Inst Neurol Sci, I-40138 Bologna, Italy

[3] Univ Bologna, Dept Histol Embryol & Appl Biol, I-40138 Bologna, Italy

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2012年 / 19卷 / 07期

关键词：

diffusion tensor imaging; restless legs syndrome; statistical parametric mapping; tract-based spatial statistics; voxel-based morphometry; MATTER ALTERATIONS;

D O I：

10.1111/j.1468-1331.2011.03604.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose: The aim of this study was to evaluate the presence of abnormalities in the brain of patients with restless legs syndrome (RLS) using voxel-based morphometry and diffusion tensor imaging (DTI). Methods: Twenty patients and twenty controls were studied. Voxel-based morphometry analysis was performed using statistical parametric mapping (SPM8) and FSL-VBM software tools. For voxel-wise analysis of DTI, tract-based spatial statistics (TBSS) and SPM8 were used. Results: Applying an appropriate threshold of probability, no significant results were found either in comparison or in correlation analyses. Conclusions: Our data argue against clear structural or microstructural abnormalities in the brain of patients with idiopathic RLS, suggesting a prevalent role of functional or metabolic impairment.

引用

页码：1045 / 1049

页数：5

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