Leptin binding in the arcuate nucleus is increased during fasting

被引：55
|
作者：
Baskin, DG
Breininger, JF
Bonigut, S
Miller, MA
机构：
[1] VA Puget Sound Hlth Care Syst, Div Endo Metab, Seattle, WA 98108 USA
[2] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA
[3] Univ Washington, Sch Med, Dept Biol Struct, Seattle, WA 98195 USA
[4] Univ Washington, Sch Med, Dept Psychiat, Seattle, WA 98195 USA
来源：
BRAIN RESEARCH | 1999年 / 828卷 / 1-2期
关键词：
hypothalamus; leptin receptor; neuropeptide Y; proopiomelanocortin; food intake;
D O I：
10.1016/S0006-8993(99)01252-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The arcuate nucleus (ARC) mediates the anorexic effects of leptin and expresses the long form (Ob-Rb) of the leptin receptor. To determine whether ARC leptin binding increases when plasma leptin levels are low during fasting, [I-125]-leptin specific binding to rat brain slices was measured by quantitative autoradiography. [I-125]-leptin specific binding was dense in the ARC and increased 2-fold after a 48-h fast (P < 0.001). These findings suggest that leptin receptor binding in the ARC is upregulated during fasting and that fasting changes the sensitivity of the ARC to leptin. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：154 / 158
页数：5
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