Astrin: A Key Player in Mitosis and Cancer

被引：6
|
作者：
Ying, Zhenguang [1 ]
Yang, Jing [1 ]
Li, Wei [1 ]
Wang, Xia [1 ]
Zhu, Zeyao [1 ]
Jiang, Weipeng [2 ]
Li, Chunman [1 ]
Sha, Ou [1 ,2 ]
机构：
[1] Shenzhen Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Anat Histol & Dev Biol, Shenzhen, Peoples R China
[2] Shenzhen Univ, Hlth Sci Ctr, Sch Dent, Shenzhen, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2020年 / 8卷
基金：
中国国家自然科学基金;
关键词：
Astrin; mitosis; kinetochore; microtubules; spindle; cancer; AURORA B KINASE; CENTROSOME DUPLICATION; PROTEIN; PROGRESSION; COMPLEX; PATHOPHYSIOLOGY; SEGREGATION; INTERACTS; COHESION;
D O I：
10.3389/fcell.2020.00866
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule and integrity of centrosomes and promoting the centriole duplication. In addition, Astrin was quite recently found to be abnormally highly expressed in a variety of cancers. Astrin promotes the development of cancer by participating in various molecular pathways and is considered as a potential prognostic and survival predictor.
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页数：8
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