Silver sulfadiazine-immobilized celluloses as biocompatible polymeric biocides

被引：27

作者：

Cao, Zhengbing ^{[1
]}

Sun, Xinbo ^{[1
]}

Yao, Jinrong ^{[2
]}

Sun, Yuyu ^{[2
,3
]}

机构：

[1] Medetech Dev Corp, Lynnwood, WA USA

[2] Fudan Univ, Dept Macromol Sci, Adv Mat Lab, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

[3] Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2013年 / 28卷 / 04期

关键词：

Silver sulfadiazine; antimicrobial; cellulose; Gram-negative bacteria; antifungal; and antiviral; ANTIMICROBIAL PEPTIDES; STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; HOSPITAL FABRICS; FELINE CALICIVIRUS; SURVIVAL; INFECTION; CONTAMINATION; ACINETOBACTER; COLIPHAGE;

D O I：

10.1177/0883911513490340

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Sulfadiazine was immobilized onto cotton cellulose using ethylene glycol diglycidyl ether as a binder. Upon treatment with diluted silver nitrate aqueous solution, the sulfadiazine moieties in the immobilized celluloses were transformed into silver-sulfadiazine coordination complexes. The resulting silver sulfadiazine-immobilized celluloses provided a 6-log reduction of 10(8) CFU mL(-1) of Staphylococcus aureus (Gram-positive bacteria), Escherichia coli (Gram-negative bacteria), methicillin-resistant Staphylococcus aureus (drug-resistant bacteria), vancomycin-resistant Enterococcus faecium (drug-resistant bacteria), and Candida albicans (fungi) in 30-60 minutes, and a 5-log reduction of 10(7) PFU mL(-1) of MS2 virus in 120 minutes. The antibacterial, antifungal, and antiviral activities were both durable and rechargeable. Additionally, trypan blue assay suggested that the new silver sulfadiazine-immobilized celluloses sustained excellent mammal cell viability, pointing to great potentials of the new materials for a broad range of health care-related applications.

引用

页码：398 / 409

页数：12

共 52 条

[1] Effect of temperature and sanitizers on the survival of feline calicivirus, Escherichia coli, and F-specific coliphage MS2 on leafy salad vegetables [J].