Early onset epilepsy is associated with increased mortality: A population-based study

被引：30

作者：

Moseley, Brian D. ^{[1
,2
]}

Wirrell, Elaine C. ^{[1
,3
]}

Wong-Kisiel, Lily C. ^{[1
,3
]}

Nickels, Katherine ^{[1
,3
]}

机构：

[1] Univ Calif Los Angeles, Dept Neurol, Div Epilepsy, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Dept Neurol, Div Clin Neurophysiol, Los Angeles, CA 90024 USA

[3] Mayo Clin, Div Child & Adolescent Neurol, Dept Neurol, Rochester, MN USA

来源：

EPILEPSY RESEARCH | 2013年 / 105卷 / 03期

关键词：

Pediatric epilepsy; Mortality; Early onset epilepsy; Neonatal onset epilepsy; ROCHESTER EPIDEMIOLOGY PROJECT; LONG-TERM; CHILDHOOD; CHILDREN; SEIZURES; COHORT; DEATH; DUTCH; ILAE;

D O I：

10.1016/j.eplepsyres.2013.03.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined mortality in early onset (age <12 months) epilepsy in a population-based group of children. Children with early onset epilepsy were significantly more likely to die (case fatality, CF 8/60 versus 8/407, p<0.001; mortality rate, MR 14.5/1000 versus 2/1000 person years; standardized mortality ratio, SMR 22.25 versus 5.67). Mortality was greater in children with malignant neonatal (age < 1 month) epilepsy (CF 4/12 versus 12/450, p < 0.001; MR 54/1000 person years versus 2.7/1000 person year; SMR 46.55 versus 7.22). Given that only 1/8 early onset epilepsy deaths was seizure-related, mortality appears to be more affected by underlying etiology. (C) 2013 Elsevier B.V. All rights reserved.

引用

收藏

页码：410 / 414

页数：5

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