Ultrasmall Gold Nanorod Vesicles with Enhanced Tumor Accumulation and Fast Excretion from the Body for Cancer Therapy

被引：269

作者：

Song, Jibin ^{[1
,2
]}

Yang, Xiangyu ^{[2
]}

Jacobson, Orit ^{[2
]}

Huang, Peng ^{[2
]}

Sun, Xiaolian ^{[2
]}

Lin, Lisen ^{[2
]}

Yan, Xuefeng ^{[2
]}

Niu, Gang ^{[2
]}

Ma, Qingjie ^{[1
]}

Chen, Xiaoyuan ^{[2
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China

[2] NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 33期

基金：

美国国家卫生研究院;

关键词：

biodegradation; nanovesicles; photoacoustic imaging; photothermal effects; ultrasmall gold nanorods; PLASMONIC VESICLES; DRUG-DELIVERY; NANOPARTICLES; RELEASE; NANOMATERIALS; PERFORMANCE; STABILITY; BIOLOGY;

D O I：

10.1002/adma.201502486

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (approximate to 60 nm) (AuNR = gold nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: approximate to 8 nm x 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as AuNR@PEG after therapy; enhanced photoacoustic and photo thermal properties; and high photothermal cancer therapy efficacy.

引用

页码：4910 / 4917

页数：8

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