Ultrasmall Gold Nanorod Vesicles with Enhanced Tumor Accumulation and Fast Excretion from the Body for Cancer Therapy

被引：263
作者：
Song, Jibin [1 ,2 ]
Yang, Xiangyu [2 ]
Jacobson, Orit [2 ]
Huang, Peng [2 ]
Sun, Xiaolian [2 ]
Lin, Lisen [2 ]
Yan, Xuefeng [2 ]
Niu, Gang [2 ]
Ma, Qingjie [1 ]
Chen, Xiaoyuan [2 ]
机构：
[1] Jilin Univ, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China
[2] NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 33期
基金：
美国国家卫生研究院;
关键词：
biodegradation; nanovesicles; photoacoustic imaging; photothermal effects; ultrasmall gold nanorods; PLASMONIC VESICLES; DRUG-DELIVERY; NANOPARTICLES; RELEASE; NANOMATERIALS; PERFORMANCE; STABILITY; BIOLOGY;
D O I：
10.1002/adma.201502486
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (approximate to 60 nm) (AuNR = gold nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: approximate to 8 nm x 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as AuNR@PEG after therapy; enhanced photoacoustic and photo thermal properties; and high photothermal cancer therapy efficacy.
引用
收藏
页码：4910 / 4917
页数：8
相关论文
共 50 条
  • [21] Stability and release performance of a series of pegylated copolymeric micelles
    Lin, WJ
    Juang, LW
    Lin, CC
    [J]. PHARMACEUTICAL RESEARCH, 2003, 20 (04) : 668 - 673
  • [22] Immunotargeted nanoshells for integrated cancer imaging and therapy
    Loo, C
    Lowery, A
    Halas, NJ
    West, J
    Drezek, R
    [J]. NANO LETTERS, 2005, 5 (04) : 709 - 711
  • [23] Liposome-Gold Nanorod Hybrids for High-Resolution Visualization Deep in Tissues
    Lozano, Neus
    Al-Jamal, Wafa' T.
    Taruttis, Adrian
    Beziere, Nicolas
    Burton, Neal C.
    Van den Bossche, Jeroen
    Mazza, Mariarosa
    Herzog, Eva
    Ntziachristos, Vasilis
    Kostarelos, Kostas
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (32) : 13256 - 13258
  • [24] Photoacoustic imaging in cancer detection, diagnosis, and treatment guidance
    Mallidi, Srivalleesha
    Luke, Geoffrey P.
    Emelianov, Stanislav
    [J]. TRENDS IN BIOTECHNOLOGY, 2011, 29 (05) : 213 - 221
  • [25] Multiwavelength Photoacoustic Imaging and Plasmon Resonance Coupling of Gold Nanoparticles for Selective Detection of Cancer
    Mallidi, Srivalleesha
    Larson, Timothy
    Tam, Justina
    Joshi, Pratixa P.
    Karpiouk, Andrei
    Sokolov, Konstantin
    Emelianov, Stanislav
    [J]. NANO LETTERS, 2009, 9 (08) : 2825 - 2831
  • [26] Amplified Photoacoustic Performance and Enhanced Photothermal Stability of Reduced Graphene Oxide Coated Gold Nanorods for Sensitive Photo acoustic Imaging
    Moon, Hyungwon
    Kumar, Dinesh
    Kim, Haemin
    Sim, Changbeom
    Chang, Jin-Ho
    Kim, Jung-Mu
    Kim, Hyuncheol
    Lim, Dong-Kwon
    [J]. ACS NANO, 2015, 9 (03) : 2711 - 2719
  • [27] Theoretical Studies of Plasmonics using Electronic Structure Methods
    Morton, Seth M.
    Silverstein, Daniel W.
    Jensen, Lasse
    [J]. CHEMICAL REVIEWS, 2011, 111 (06) : 3962 - 3994
  • [28] Structural and functional photoacoustic molecular tomography aided by emerging contrast agents
    Nie, Liming
    Chen, Xiaoyuan
    [J]. CHEMICAL SOCIETY REVIEWS, 2014, 43 (20) : 7132 - 7170
  • [29] PEGylated nanoparticles for biological and pharmaceutical applications
    Otsuka, H
    Nagasaki, Y
    Kataoka, K
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (03) : 403 - 419
  • [30] Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation
    Redhead, HM
    Davis, SS
    Illum, L
    [J]. JOURNAL OF CONTROLLED RELEASE, 2001, 70 (03) : 353 - 363
12345