Ultrasmall Gold Nanorod Vesicles with Enhanced Tumor Accumulation and Fast Excretion from the Body for Cancer Therapy

被引：263
作者：
Song, Jibin [1 ,2 ]
Yang, Xiangyu [2 ]
Jacobson, Orit [2 ]
Huang, Peng [2 ]
Sun, Xiaolian [2 ]
Lin, Lisen [2 ]
Yan, Xuefeng [2 ]
Niu, Gang [2 ]
Ma, Qingjie [1 ]
Chen, Xiaoyuan [2 ]
机构：
[1] Jilin Univ, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China
[2] NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 33期
基金：
美国国家卫生研究院;
关键词：
biodegradation; nanovesicles; photoacoustic imaging; photothermal effects; ultrasmall gold nanorods; PLASMONIC VESICLES; DRUG-DELIVERY; NANOPARTICLES; RELEASE; NANOMATERIALS; PERFORMANCE; STABILITY; BIOLOGY;
D O I：
10.1002/adma.201502486
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (approximate to 60 nm) (AuNR = gold nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: approximate to 8 nm x 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as AuNR@PEG after therapy; enhanced photoacoustic and photo thermal properties; and high photothermal cancer therapy efficacy.
引用
收藏
页码：4910 / 4917
页数：8
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