Ultrasmall Gold Nanorod Vesicles with Enhanced Tumor Accumulation and Fast Excretion from the Body for Cancer Therapy

被引：269

作者：

Song, Jibin ^{[1
,2
]}

Yang, Xiangyu ^{[2
]}

Jacobson, Orit ^{[2
]}

Huang, Peng ^{[2
]}

Sun, Xiaolian ^{[2
]}

Lin, Lisen ^{[2
]}

Yan, Xuefeng ^{[2
]}

Niu, Gang ^{[2
]}

Ma, Qingjie ^{[1
]}

Chen, Xiaoyuan ^{[2
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China

[2] NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 33期

基金：

美国国家卫生研究院;

关键词：

biodegradation; nanovesicles; photoacoustic imaging; photothermal effects; ultrasmall gold nanorods; PLASMONIC VESICLES; DRUG-DELIVERY; NANOPARTICLES; RELEASE; NANOMATERIALS; PERFORMANCE; STABILITY; BIOLOGY;

D O I：

10.1002/adma.201502486

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (approximate to 60 nm) (AuNR = gold nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: approximate to 8 nm x 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as AuNR@PEG after therapy; enhanced photoacoustic and photo thermal properties; and high photothermal cancer therapy efficacy.

引用

页码：4910 / 4917

页数：8

共 50 条

[1] Synthesis and Optical Properties of Small Au Nanorods Using a Seedless Growth Technique [J].

Ali, Moustafa R. K. ;

Snyder, Brian ;

El-Sayed, Mostafa A. .

LANGMUIR, 2012, 28 (25) :9807-9815

[2] Single Unlabeled Protein Detection on Individual Plasmonic Nanoparticles [J].

Ament, Irene ;

Prasad, Janak ;

Henkel, Andreas ;

Schmachtel, Sebastian ;

Soennichsen, Carsten .

NANO LETTERS, 2012, 12 (02) :1092-1095

[3] Biosensing with plasmonic nanosensors [J].

Anker, Jeffrey N. ;

Hall, W. Paige ;

Lyandres, Olga ;

Shah, Nilam C. ;

Zhao, Jing ;

Van Duyne, Richard P. .

NATURE MATERIALS, 2008, 7 (06) :442-453

[4] Plasmon light scattering in biology and medicine: new sensing approaches, visions and perspectives [J].

Aslan, K ;

Lakowicz, JR ;

Geddes, CD .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2005, 9 (05) :538-544

[5] PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation, in vitro drug release and in Vivo drug residence in blood properties [J].

Avgoustakis, K ;

Beletsi, A ;

Panagi, Z ;

Klepetsanis, P ;

Karydas, AG ;

Ithakissios, DS .

JOURNAL OF CONTROLLED RELEASE, 2002, 79 (1-3) :123-135

[6]

Bardhan R., 2011, ACCOUNTS CHEM RES, V2011, P936

[7] NANOMEDICINE Shake up the drug containers [J].

Barenholz, Yechezkel .

NATURE NANOTECHNOLOGY, 2012, 7 (08) :483-484

[8] Tumor Regression In Vivo by Photothermal Therapy Based on Gold-Nanorod-Loaded, Functional Nanocarriers [J].

Choi, Won Il ;

Kim, Ja-Young ;

Kang, Chul ;

Byeon, Clare C. ;

Kim, Young Ha ;

Tee, Giyoong .

ACS NANO, 2011, 5 (03) :1995-2003

[9] Plasmonic nanocomposites: polymer-guided strategies for assembling metal nanoparticles [J].

Gao, Bo ;

Rozin, Matthew J. ;

Tao, Andrea R. .

NANOSCALE, 2013, 5 (13) :5677-5691

[10] Polymeric Nanomaterials for Islet Targeting and Immunotherapeutic Delivery [J].

Ghosh, Kaustabh ;

Kanapathipillai, Mathumai ;

Korin, Netanel ;

McCarthy, Jason R. ;

Ingber, Donald E. .

NANO LETTERS, 2012, 12 (01) :203-208

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