CuI/PPh3 catalyzed Sonogashira coupling reaction of aryl iodides with terminal alkynes in water in the absence of palladium

被引：54

作者：

Guan, Jin Tao ^{[1
]}

Yu, Guang-Ao ^{[1
]}

Chen, Lei ^{[1
]}

Weng, Tan Qing ^{[1
]}

Yuan, Jing Jing ^{[1
]}

Liu, Sheng Hua ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2009年 / 23卷 / 02期

基金：

中国国家自然科学基金;

关键词：

water; copper(I) iodide; aryl iodide; terminal alkyne; Sonogashira coupling reaction; LIGAND-FREE; CONJUGATED ENYNES; ORGANIC-CHEMISTRY; SUZUKI-MIYAURA; VINYL IODIDES; COPPER; HALIDES; DERIVATIVES; ACETYLENES; 1-ALKYNES;

D O I：

10.1002/aoc.1474

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The Sonogashira cross-coupling of aryl iodides with terminal alkynes catalyzed by a simple and inexpensive catalyst CuI/PPh3 in water as the sole solvent has been reported. In the presence of CuI/PPh3, with KOH used as a base, a number of aryl iodides were treated with alkynes to afford the corresponding products in moderate to excellent yields. Copyright (c) 2008 John Wiley & Sons, Ltd.

引用

页码：75 / 77

页数：3

共 42 条

[1] General catalysts for the Suzuki-Miyaura and Sonogashira coupling reactions of aryl chlorides and for the coupling of challenging substrate combinations in water [J].